Newcastle disease vaccines

Newcastle disease (ND) is a worldwide problem with severe economic implications, affecting chickens, turkeys and other birds. Newcastle disease virus (NDV), a member of the Paramyxoviridae group can cause disease of diverse severity in accordance with environmental factors. NDV strains are classifie...

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Bibliographic Details
Published in:Biotechnology advances 1998-03, Vol.16 (2), p.343-366
Main Authors: Gallili, Gilad E., Ben-Nathan, David
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Microbiology
Newcastle disease
Paramyxovirus
poultry diseases
Production of active biomolecules
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
vaccine
Vaccins
Virology
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Summary:Newcastle disease (ND) is a worldwide problem with severe economic implications, affecting chickens, turkeys and other birds. Newcastle disease virus (NDV), a member of the Paramyxoviridae group can cause disease of diverse severity in accordance with environmental factors. NDV strains are classified according to their virulence into three categories. The lentogenic strains are very mild and naturally inhabit healthy flocks. They can be used as live vaccines even for young chicks. Killed vaccines can be produced from the same viruses following inactivation. Mesogenic ND viruses, which cause mild or inapparent respiratory infections, have recently been banned in many countries even for killed vaccine production due to fears of disease emergence. Velogenic strains are the causative agents of the disease and can be used for the purpose of vaccine challenge test. Production and use of Newcastle disease vaccines are discussed in this review.
ISSN:0734-9750
1873-1899
DOI:10.1016/S0734-9750(97)00081-5