Neuropsychological and neuroimaging correlates in corticobasal degeneration

The aim of this study was to correlate neuropsychological and neuroimaging findings in corticobasal degeneration (CBD). Three patients with clinical criteria for CBD were examined by means of neuropsychological tests, brain magnetic resonance imaging (MRI), and flow and metabolism neuroimaging techn...

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Published in:Italian journal of neurological sciences 1998-10, Vol.19 (5), p.321-328
Main Authors: Frasson, E, Moretto, G, Beltramello, A, Smania, N, Pampanin, M, Stegagno, C, Tanel, R, Rizzuto, N
Format: Article
Language:English
Subjects:
Aged
Brain - pathology
Brain - physiopathology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neurodegenerative Diseases - pathology
Neurodegenerative Diseases - physiopathology
Neurodegenerative Diseases - psychology
Neuropsychological Tests
Psychomotor Performance - physiology
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Summary:The aim of this study was to correlate neuropsychological and neuroimaging findings in corticobasal degeneration (CBD). Three patients with clinical criteria for CBD were examined by means of neuropsychological tests, brain magnetic resonance imaging (MRI), and flow and metabolism neuroimaging techniques. Neuropsychological assessment revealed impairment in executive functions, manual dexterity and motor programming with significant asymmetry between upper limbs. Ideomotor and oral apraxia were also detected, and memory deficits were observed in one patient. MRI revealed cortical dilation of the frontal and peri-rolandic regions, symmetrical in one case and asymmetrical in the other two cases. An increased T2 signal intensity in the posterolateral putamen and substantia nigra ipsilateral to the cortical atrophy was observed in one patient. Asymmetries of both frontal and parietal cortices and basal ganglia were detected in all three patients by 18-fluorodeoxyglucose positron emission tomography; temporal region hypometabolism was associated in one patient. These cortical and subcortical asymmetries were observed in two patients by single photon emission tomography with the tracer technetium Tc 99m hexamethyl propylenamine oxime; cortical asymmetry was observed in only one patient. The results showed that functional neuroimaging findings correlated well with neuropsychological aspects in CBD. Neuroimaging and neuropsychological correlations may contribute toward understanding anatomical and functional abnormalities associated with this neurodegenerative disorder.
ISSN:0392-0461
1590-3478
1126-5442
DOI:10.1007/bf00713860