Central motor conduction after magnetic stimulation in diabetes

Central motor conduction times (CMCTs), obtained by means of magnetic stimulation of the motor cortex and spinal roots, were studied in 138 patients affected by diabetes mellitus but with no signs or symptoms of central nervous system (CNS) involvement. CMCTs were significantly increased in diabetic...

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Bibliographic Details
Published in:Italian journal of neurological sciences 1998-02, Vol.19 (1), p.10-14
Main Authors: Moglia, A, Arrigo, A, Maurelli, M, Alfonsi, E, Bodini, A, Lozza, A, Tenconi, M T, Solerte, S B, Ferrari, E
Format: Article
Language:English
Subjects:
Adult
Autonomic nervous system
Central nervous system
Cortex (motor)
Diabetes
Diabetes mellitus (insulin dependent)
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 2 - complications
Diabetic Neuropathies - diagnosis
Diabetic Neuropathies - physiopathology
Diabetic neuropathy
Electric Stimulation
Female
Humans
Insulin
Linear Models
Magnetic fields
Magnetics
Male
Middle Aged
Motor Cortex - cytology
Motor Cortex - physiopathology
Motor Neurons - physiology
Nephropathy
Neural Conduction
Neurosciences
Reaction Time - physiology
Retinopathy
Spinal Nerve Roots - cytology
Spinal Nerve Roots - physiopathology
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Summary:Central motor conduction times (CMCTs), obtained by means of magnetic stimulation of the motor cortex and spinal roots, were studied in 138 patients affected by diabetes mellitus but with no signs or symptoms of central nervous system (CNS) involvement. CMCTs were significantly increased in diabetic patients (p < 0.001, t-test) with respect to normal controls, with values exceeding upper confidence limits (mean +/- 2.5 SD of controls) in about 30% of patients. There was no correlation between CMCT delay and type of diabetes (insulin-dependent or non-insulin-dependent), patient age, disease duration, degree of metabolic control compensation, presence or absence of retinopathy or nephropathy, and presence or absence of peripheral or autonomic neuropathy. CNS involvement in diabetes mellitus is discussed. Particular emphasis is given to the sensitivity and reliability of CMCTs obtained by means of magnetic stimulation as a tool in the early diagnosis of CNS functional alterations in diabetes mellitus.
ISSN:0392-0461
1590-1874
1126-5442
1590-3478
DOI:10.1007/BF03028805