The 5'-terminal Non-coding Region of Murray Valley Encephalitis Virus RNA is Highly Conserved

Department of Microbiology, Queen Elizabeth II Medical Centre, University of Western Australia, Nedlands, Perth 6009, Australia The 5' non-coding region of the genomes of 11 isolates of Murray Valley encephalitis virus from Australia and Papua New Guinea were examined by primer extension sequen...

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Bibliographic Details
Published in:Journal of general virology 1990-01, Vol.71 (1), p.241-245
Main Authors: Coelen, Robert J, Mackenzie, John S
Format: Article
Language:English
Subjects:
Animals
Australia
Base Sequence
Biological and medical sciences
Flavivirus - genetics
Fundamental and applied biological sciences. Psychology
Genetics
Humans
Microbiology
Molecular Sequence Data
Papua New Guinea
RNA, Viral - genetics
Sequence Homology, Nucleic Acid
Vero Cells
Virology
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Summary:Department of Microbiology, Queen Elizabeth II Medical Centre, University of Western Australia, Nedlands, Perth 6009, Australia The 5' non-coding region of the genomes of 11 isolates of Murray Valley encephalitis virus from Australia and Papua New Guinea were examined by primer extension sequencing. Although the 5' non-coding region of all isolates was found to be highly conserved, three isolates were significantly different in that they contained extra uridine residues. Two of these isolates from Papua New Guinea contained an extra uridine residue, nominally positioned after nucleotide 54, which was absent from all but one of the Australian isolates tested. This isolate (OR 156) contained a further uridine residue at the same site. These results provide further support for earlier observations on the genetic relationships between these isolates, in particular that OR 156 is more closely related to the Papua New Guinea strains than to the Australian strains. Received 10 April 1989; accepted 12 September 1989.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-71-1-241