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Catechol estrogens as inhibitors of leukotriene synthesis
Estrogens have a beneficial effect on atherosclerosis and osteoporosis after menopause, but their exact mechanism of action is still unknown. The aim of the present study was to investigate the effects of estradiol and its metabolites catechol estrogens on arachidonic acid metabolism in vitro. Estra...
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Published in: | Biochemical pharmacology 1998, Vol.55 (1), p.101-104 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Estrogens have a beneficial effect on atherosclerosis and osteoporosis after menopause, but their exact mechanism of action is still unknown. The aim of the present study was to investigate the effects of estradiol and its metabolites catechol estrogens on arachidonic acid metabolism
in vitro. Estradiol had no effect on arachidonic acid metabolism up to 33 μM in A23187-stimulated human whole blood. All catechol estrogens (2-hydroxyestradiol, 2-hydroxyestrone, 4-hydroxyestradiol and 4-hydroxyestrone) had similar kinds of actions on arachidonic acid metabolism, being over ten times more potent inhibitors of leukotriene synthesis (
ic
50 values 0.044-0.16 μM) than thromboxane (
ic
50 values 0.99-2.1 μM) and prostaglandin E
2 synthesis (
ic
50 values 0.84-5.5 μM). It is suggested that some of the protective actions of estrogens—e.g., on atherosclerosis and osteoporosis—may be related to the inhibition of leukotriene synthesis by catechol estrogens. |
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ISSN: | 0006-2952 1873-2968 |
DOI: | 10.1016/S0006-2952(97)00398-5 |