Ontogeny of lh/hcg receptor gene expression in male and female pig reproductive tracts

The receptors for LH, located in the gonadal tissues of the male and female, mediate stimulation of ovarian and testicular steroidogenesis by the pituitary. However, it is known that several animal and human nongonadal reproductive tissues also contain functional LH receptors. This study was underta...

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Bibliographic Details
Published in:Theriogenology 1997-07, Vol.48 (1), p.51-62
Main Authors: Derecka, K., Ziecik, A.J.
Format: Article
Language:English
Subjects:
ANIMAL NOUVEAU NE
ANIMAL RECIEN NACIDO
ARN MENSAJERO
ARN MESSAGER
BIOLOGICAL DEVELOPMENT
CERDO
DESARROLLO BIOLOGICO
DEVELOPPEMENT BIOLOGIQUE
EPIDIDYMIS
EXPRESION GENICA
EXPRESSION DES GENES
FETO
FOETUS
GENE EXPRESSION
GONADOTROPHINE
GONADOTROPINAS
GONADOTROPINS
gonads
HORMONE RECEPTORS
luteinizing hormone receptor
MESSENGER RNA
NEWBORN ANIMALS
ontogeny
OVAIRE
OVARIES
OVARIOS
pigs
PORCIN
RECEPTEUR D'HORMONE
RECEPTORES DE HORMONAS
SWINE
TESTES
TESTICULE
TESTICULOS
UTERO
UTERUS
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Summary:The receptors for LH, located in the gonadal tissues of the male and female, mediate stimulation of ovarian and testicular steroidogenesis by the pituitary. However, it is known that several animal and human nongonadal reproductive tissues also contain functional LH receptors. This study was undertaken to compare expression of LH/hCG receptor gene expression in gonadal and nongonadal reproductive tissue of the male and female fetal and neonatal pigs. We used reverse transcription-polymerase chain reaction (RT-PCR) to examine the onset of LH/hCG receptor gene expression in both gonadal and nongonadal tissues during ontogeny of the pig. According to our results the expression of LH/hCG receptor gene as measured by the presence in its extracellular domain starts between 30 and 40 d post coitum in the testis and between 40 and 48 d post coitum in the ovary. The expression of extragonadal LH/hCG receptor gene in the uterus occurred between Days 48 and 103 post coitum. When detected, the extracellular domain of LH/hCG receptor gene was expressed permanently both in gonadal and nongonadal porcine reproductive tissues. We also showed that LH/hCG receptors are expressed in the pig epididymis on Day 1 of neonatal life.
ISSN:0093-691X
1879-3231
DOI:10.1016/S0093-691X(97)00201-X