Characterization of an Avian Influenza A (H5N1) Virus Isolated from a Child with a Fatal Respiratory Illness

An avian H5N1 influenza A virus (A/Hong Kong/156/97) was isolated from a tracheal aspirate obtained from a 3-year-old child in Hong Kong with a fatal illness consistent with influenza. Serologic analysis indicated the presence of an H5 hemagglutinin. All eight RNA segments were derived from an avian...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1998-01, Vol.279 (5349), p.393-396
Main Authors: Subbarao, K, Klimov, A, Katz, J, Regnery, H, Lim, W, Hall, H, Perdue, M, Swayne, D, Bender, C, Huang, J
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Attrition (Research Studies)
Avian influenza
Basic amino acids
Biological and medical sciences
Cell Line
Chickens
Child, Preschool
children
Children & youth
Disease Outbreaks
Diseases
Endothelial cells
Fatal Outcome
Female
Genes, Viral
H5N1 subtype influenza A virus
Hemagglutinin Glycoproteins, Influenza Virus - chemistry
Hemagglutinin Glycoproteins, Influenza Virus - genetics
hemagglutinins
Hong Kong - epidemiology
human health
Human viral diseases
Humans
Infectious diseases
Influenza A virus
Influenza A virus - genetics
Influenza A virus - isolation & purification
Influenza A virus - pathogenicity
Influenza A Virus, H5N1 Subtype
Influenza in Birds - virology
Influenza viruses
Influenza, Human - epidemiology
Influenza, Human - virology
Literary Devices
Male
Medical research
Medical sciences
Molecular Sequence Data
Monoclonal antibodies
Neuraminidase - genetics
Orthomyxoviridae
Phylogeny
Poultry
respiratory tract diseases
RNA
Ventilation
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Virulence
Virus Replication
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An avian H5N1 influenza A virus (A/Hong Kong/156/97) was isolated from a tracheal aspirate obtained from a 3-year-old child in Hong Kong with a fatal illness consistent with influenza. Serologic analysis indicated the presence of an H5 hemagglutinin. All eight RNA segments were derived from an avian influenza A virus. The hemagglutinin contained multiple basic amino acids adjacent to the cleavage site, a feature characteristic of highly pathogenic avian influenza A viruses. The virus caused 87.5 to 100 percent mortality in experimentally inoculated White Plymouth Rock and White Leghorn chickens. These results may have implications for global influenza surveillance and planning for pandemic influenza.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.279.5349.393