Predictive power of the relative lymphocyte concentration in patients with advanced heart failure

The physiological stress suffered by patients with heart failure results in an increased production of cortisol and a shift in the leukocyte differential toward a decreased percentage of lymphocytes (%L). The purpose of this study was to determine the prognostic significance of a low %L in advanced...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1998-01, Vol.97 (1), p.19-22
Main Authors: OMMEN, S. R, HODGE, D. O, RODEHEFFER, R. J, MCGREGOR, C. G. A, THOMSON, S. P, GIBBONS, R. J
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Biological and medical sciences
Cardiology. Vascular system
Female
Heart
Heart Failure - blood
Heart Failure - mortality
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Lymphocyte Count
Male
Medical sciences
Middle Aged
Multivariate Analysis
Prognosis
Proportional Hazards Models
Retrospective Studies
Survival Rate
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Summary:The physiological stress suffered by patients with heart failure results in an increased production of cortisol and a shift in the leukocyte differential toward a decreased percentage of lymphocytes (%L). The purpose of this study was to determine the prognostic significance of a low %L in advanced heart failure. Patients evaluated in our cardiac transplantation clinic between April 1988 and July 1995 were retrospectively reviewed (n=263). Fifty-two patients were excluded because they had recent trauma, infection, surgery, myocardial infarction, corticosteroid use, or history of malignancy. In the remaining 211 patients, we used Cox proportional hazards analysis to examine the association between survival and transplant-free survival with baseline variables. Univariate analysis showed a significant association between time to death and %L (P=.004), New York Heart Association (NYHA) class (P=.002), and maximal oxygen uptake (P=.05). Univariate analysis of the end point of survival free from transplantation yielded similar results. One- and 4-year survival rates for patients with a low %L (
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.97.1.19