Iodine-131 MIBG Imaging in Multiple Endocrine Neoplasia Type 2B

A 16-year-old boy had a swollen neck that was a result of multiple endocrine neoplasia Type 2B (MEN 2B). CT revealed bilateral thyroid tumors, swelling of right cervical lymph nodes, and slight enlargement of the right adrenal gland. I-131 metaiodobenzylguanidine (MIBG) scintigraphy demonstrated inc...

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Bibliographic Details
Published in:Clinical nuclear medicine 1998-01, Vol.23 (1), p.13-15
Main Authors: YAMAMOTO, YUKA, ISOBE, YUKO, NISHIYAMA, YOSHIHIRO, TAKASHIMA, HITOSHI, OHKAWA, MOTOOMI, KIHARA, MINORU, MATSUSAKA, KENICHI, MIYAUCHI, AKIRA, KOBAYASHI, SHOJI, TANABE, MASATADA
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine
Adolescent
Adrenal Gland Neoplasms - diagnostic imaging
Adrenal Gland Neoplasms - pathology
Adrenal Medulla - diagnostic imaging
Adrenal Medulla - pathology
Adrenalectomy
Carcinoma, Medullary - diagnostic imaging
Carcinoma, Medullary - secondary
Humans
Hyperplasia
Iodine Radioisotopes
Lymphatic Metastasis - diagnostic imaging
Male
Multiple Endocrine Neoplasia Type 2b - diagnostic imaging
Neoplasm Staging
Pheochromocytoma - pathology
Precancerous Conditions - pathology
Radionuclide Imaging
Radiopharmaceuticals
Thyroid Neoplasms - diagnostic imaging
Thyroidectomy
Tomography, X-Ray Computed
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Summary:A 16-year-old boy had a swollen neck that was a result of multiple endocrine neoplasia Type 2B (MEN 2B). CT revealed bilateral thyroid tumors, swelling of right cervical lymph nodes, and slight enlargement of the right adrenal gland. I-131 metaiodobenzylguanidine (MIBG) scintigraphy demonstrated increased uptake in the right adrenal gland and the left thyroid tumor, but no abnormal uptake in the right thyroid tumor and the right cervical lymph nodes. Postoperative pathologic findings were consistent with the diagnosis of right adrenal medullary hyperplasia, which is a precursor of pheochromocytoma. In patients with MEN 2B, I-131 MIBG scintigraphy in conjunction with CT of the adrenal glands should be performed to determine the disease stage of the adrenal medullae. In the cervical region, the diagnosis was medullary thyroid carcinoma (MTC) in both thyroid tumors and metastases in the right cervical lymph nodes. The right MTC was more aggressive than the left MTC. It is interesting that not all sites of known MTC take up I-131 MIBG to the same degree.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199801000-00005