Colocalization of Inhibitory Mediators, NO, VIP and Galanin, in Canine Enteric Nerves

Wang, Y. F., Y. K. Mao, J. E. T. Fox–threlkeld, T. J. M cDonald and E. E. Daniel. Colocalization of inhibitory mediators, NO, VIP and Galanin, in canine enteric nerves. Peptides 19(1), 99–112, 1998.—The colocalization of three putative inhibitory mediators of enteric nerves, vasoactive intestinal pe...

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Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1998, Vol.19 (1), p.99-112
Main Authors: Wang, Y.F, Mao, Y.K, Fox–Threlkeld, J.E.T, McDonald, T.J, Daniel, E.E
Format: Article
Language:English
Subjects:
Animals
Colon - chemistry
Colon - innervation
Descending inhibition
Dihydrolipoamide Dehydrogenase - metabolism
Dogs
Female
Galanin
Galanin - analysis
Galanin - immunology
Ileum - chemistry
Ileum - innervation
Immunohistochemistry
Inhibitory junction potentials
Male
Microscopy, Fluorescence
Myenteric Plexus - chemistry
Myenteric Plexus - cytology
NADP - metabolism
Neuropeptides - analysis
Nitric Oxide - analysis
Nitric Oxide - pharmacology
Nitric oxide synthase
Nitric Oxide Synthase - analysis
Nitric Oxide Synthase - immunology
Pyloric Antrum - chemistry
Pyloric Antrum - innervation
Vasoactive intestinal peptide
Vasoactive Intestinal Peptide - analysis
Vasoactive Intestinal Peptide - immunology
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Summary:Wang, Y. F., Y. K. Mao, J. E. T. Fox–threlkeld, T. J. M cDonald and E. E. Daniel. Colocalization of inhibitory mediators, NO, VIP and Galanin, in canine enteric nerves. Peptides 19(1), 99–112, 1998.—The colocalization of three putative inhibitory mediators of enteric nerves, vasoactive intestinal peptide (VIP), galanin (GAL) and nitric oxide synthase (nNOS), was examined in the myenteric plexus of canine antrum, intestine and colon. Many ileal and colonic neurons contained nNOS-immunoreactive (nNOS-IR) activity with some also containing VIP-IR; only a few neurons also contained GAL-IR. Ileal and colonic VIP-IR nerves often appeared to be interneurons innervating nNOS nerves. Many antral neurons contained VIP-IR with nearly all also containing GAL-IR. A few also contained nNOS-IR. The predominance of nNOS-IR neurons relative to VIP-IR and GAL-IR neurons in the ileal and colonic, but not the antral, myenteric plexus is consistent with NO being the primary inhibitory mediator in the intestine but not in the antrum.
ISSN:0196-9781
1873-5169
DOI:10.1016/S0196-9781(97)00262-3