Clinical experiences with fusidic acid in cystic fibrosis patients

A survey of Staphylococcus aureus lung infection in 243 patients with cystic fibrosis (CF) was conducted between 1986 and 1988. A total of 217 patients (89%) received 1605 courses of anti-staphylococcal therapy given during this period. The majority of courses comprised combined therapy with two ant...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1990-02, Vol.25, p.45-52
Main Authors: JENSEN, T, LANNG, S, FABER, M, ROSDAHL, V. T, HOÊIBY, N, KOCH, C
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteriophage Typing
Biological and medical sciences
Cystic Fibrosis - complications
Denmark
Dicloxacillin - therapeutic use
Fusidic Acid - therapeutic use
Humans
Immunoelectrophoresis
Lung Diseases - complications
Lung Diseases - drug therapy
Lung Diseases - microbiology
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Precipitin Tests
Respiratory Tract Infections - complications
Respiratory Tract Infections - drug therapy
Respiratory Tract Infections - microbiology
Staphylococcal Infections - complications
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcus aureus - drug effects
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Summary:A survey of Staphylococcus aureus lung infection in 243 patients with cystic fibrosis (CF) was conducted between 1986 and 1988. A total of 217 patients (89%) received 1605 courses of anti-staphylococcal therapy given during this period. The majority of courses comprised combined therapy with two anti-staphylococcal drugs. The combination of dicloxacillin and fusidic acid was employed most frequently. Some patients were given other anti-staphylococcal regimens, because of penicillin allergy (14 cases) or dyspeptic side effects with fusidic acid (21 patients). A small but significant increase in precipitins against S. aureus was observed during the study period. Bacterial resistance to the anti-staphylococcal drugs used remained at a low level (strains resistant to methicillin less than 0.1%, strains resistant to fusidic acid 1.2%). When the isolates were compared with 56,140 strains of S. aureus isolated from non-CF patients hospitalized in Denmark over the same period, no differences in phagetypes or in antibiotic resistance were seen, indicating that selection of strains and cross infection do not seem to be a major problem in CF patients.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/25.suppl_B.45