Endogenous and Exogenous Reinfections by Haemophilus influenzae in Patients with Chronic Obstructive Pulmonary Disease: The Effect of Antibiotic Treatment on Persistence

To analyze whether exacerbations in chronic obstructive pulmonary disease (COPD) coincide with reinfection by Haemophilus influenzae, 16COPD patients were studied longitudinally for 3 years. Exacerbations coincided with reinfection by H. influenzae, either endogenous, by a strain with a DNA fingerpr...

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Bibliographic Details
Published in:The Journal of infectious diseases 1990-03, Vol.161 (3), p.512-517
Main Authors: Groeneveld, Kees, van Alphen, Loek, Eijk, Paul P., Visschers, Gert, Jansen, Henk M., Zanen, H. C.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - therapeutic use
Antibiotics
Bacterial Outer Membrane Proteins - analysis
Chronic obstructive pulmonary disease
DNA
DNA, Bacterial - analysis
Electrophoresis, Polyacrylamide Gel
Haemophilus Infections - drug therapy
Haemophilus Infections - etiology
Haemophilus Infections - microbiology
Haemophilus influenzae
Haemophilus influenzae - classification
Haemophilus influenzae - genetics
Humans
Infections
Longitudinal Studies
Lung Diseases, Obstructive - complications
Major Articles
Membrane proteins
Middle Aged
Nucleotide Mapping
Nursing homes
Pharynx - microbiology
Recurrence
Reinfection
Sputum
Sputum - microbiology
Throat
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Summary:To analyze whether exacerbations in chronic obstructive pulmonary disease (COPD) coincide with reinfection by Haemophilus influenzae, 16COPD patients were studied longitudinally for 3 years. Exacerbations coincided with reinfection by H. influenzae, either endogenous, by a strain with a DNA fingerprint indistinguishable from the strain previously present but with another major outer membrane protein (MOMP) pattern (2 patients), or exogenous, by a strain with a different DNA fingerprint and MOMP pattern (3 patients). The other patients, remaining in an infectious state without clear exacerbations for longer periods, were persistently infected by a particular H. influenzae strain (median persistence time, 5.5 months; range, 2-23 months). Of8 antibiotic-treated patients, 7 remained infected by H. influenzae with the same DNA fingerprint, although all strains were sensitive to the antibiotics prescribed. Results of the study suggested that exacerbations in COPD patients coincide with endogenous or exogenous reinfection by H. influenzae, persistently infected patients keep the same H. influenzae strain for longer periods, and antibiotic treatment was not effective in eradicating H. influenzae.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/161.3.512