Antibody to p40tax Protein of Human T Cell Leukemia Virus 1 and Infectivity

To investigate the physiologic significance of antibody to human T cell leukemia virus type 1 (HTLV-1) tax gene product (p40tax), 147 male and 243 female HTLV-1 carriers were examined for anti-p40tax, and 104 carriers were checked for anti-p40tax an average of 5.4 times during an 8-year period. Prev...

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Bibliographic Details
Published in:The Journal of infectious diseases 1990-03, Vol.161 (3), p.426-429
Main Authors: Kashiwagi, Seizaburo, Kajiyama, Wataru, Hayashi, Jun, Noguchi, Akinori, Nakashima, Koya, Nomura, Hideyuki, Ikematsu, Hideyuki, Sawada, Thkashi, Kida, Shigeru, Koide, Atsushi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
AIDS/HIV
Carrier State - epidemiology
Carrier State - immunology
Child
Child, Preschool
Female
HTLV-I Antibodies - analysis
HTLV-I Infections - epidemiology
HTLV-I Infections - immunology
HTLV-I Infections - transmission
Human T-lymphotropic virus 1 - immunology
Human T-lymphotropic virus 1 - physiology
Humans
Japan - epidemiology
Male
Middle Aged
Prevalence
Sex Factors
Trans-Activators - immunology
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Summary:To investigate the physiologic significance of antibody to human T cell leukemia virus type 1 (HTLV-1) tax gene product (p40tax), 147 male and 243 female HTLV-1 carriers were examined for anti-p40tax, and 104 carriers were checked for anti-p40tax an average of 5.4 times during an 8-year period. Prevalence of anti-p40tax was significantly higher in female (62.6%) than in male subjects (51.0%; P < .05). Anti-p40tax status did not change in most during the observation period. There were significantly more HTLV-1 carriers among children of anti-p40tax-positive mothers (45.3%) than among those from anti-p4()tax-negative mothers (20.0%; P < .01). However, no significant difference was observed between wives of p40tax-positiveand -negative men. The p40tax antibody may be a marker of relative infectivity of HTLV-, albeit an imperfect one.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/161.3.426