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Antibody to p40tax Protein of Human T Cell Leukemia Virus 1 and Infectivity

To investigate the physiologic significance of antibody to human T cell leukemia virus type 1 (HTLV-1) tax gene product (p40tax), 147 male and 243 female HTLV-1 carriers were examined for anti-p40tax, and 104 carriers were checked for anti-p40tax an average of 5.4 times during an 8-year period. Prev...

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Published in:	The Journal of infectious diseases 1990-03, Vol.161 (3), p.426-429
Main Authors:	Kashiwagi, Seizaburo, Kajiyama, Wataru, Hayashi, Jun, Noguchi, Akinori, Nakashima, Koya, Nomura, Hideyuki, Ikematsu, Hideyuki, Sawada, Thkashi, Kida, Shigeru, Koide, Atsushi
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Language:	English
Subjects:	Adolescent Adult Age Factors Aged Aged, 80 and over AIDS/HIV Carrier State - epidemiology Carrier State - immunology Child Child, Preschool Female HTLV-I Antibodies - analysis HTLV-I Infections - epidemiology HTLV-I Infections - immunology HTLV-I Infections - transmission Human T-lymphotropic virus 1 - immunology Human T-lymphotropic virus 1 - physiology Humans Japan - epidemiology Male Middle Aged Prevalence Sex Factors Trans-Activators - immunology
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container_start_page	426
container_title	The Journal of infectious diseases
container_volume	161
creator	Kashiwagi, Seizaburo Kajiyama, Wataru Hayashi, Jun Noguchi, Akinori Nakashima, Koya Nomura, Hideyuki Ikematsu, Hideyuki Sawada, Thkashi Kida, Shigeru Koide, Atsushi
description	To investigate the physiologic significance of antibody to human T cell leukemia virus type 1 (HTLV-1) tax gene product (p40tax), 147 male and 243 female HTLV-1 carriers were examined for anti-p40tax, and 104 carriers were checked for anti-p40tax an average of 5.4 times during an 8-year period. Prevalence of anti-p40tax was significantly higher in female (62.6%) than in male subjects (51.0%; P < .05). Anti-p40tax status did not change in most during the observation period. There were significantly more HTLV-1 carriers among children of anti-p40tax-positive mothers (45.3%) than among those from anti-p4()tax-negative mothers (20.0%; P < .01). However, no significant difference was observed between wives of p40tax-positiveand -negative men. The p40tax antibody may be a marker of relative infectivity of HTLV-, albeit an imperfect one.
doi_str_mv	10.1093/infdis/161.3.426
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Prevalence of anti-p40tax was significantly higher in female (62.6%) than in male subjects (51.0%; P < .05). Anti-p40tax status did not change in most during the observation period. There were significantly more HTLV-1 carriers among children of anti-p40tax-positive mothers (45.3%) than among those from anti-p4()tax-negative mothers (20.0%; P < .01). However, no significant difference was observed between wives of p40tax-positiveand -negative men. The p40tax antibody may be a marker of relative infectivity of HTLV-, albeit an imperfect one.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/161.3.426</identifier><identifier>PMID: 2313123</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; AIDS/HIV ; Carrier State - epidemiology ; Carrier State - immunology ; Child ; Child, Preschool ; Female ; HTLV-I Antibodies - analysis ; HTLV-I Infections - epidemiology ; HTLV-I Infections - immunology ; HTLV-I Infections - transmission ; Human T-lymphotropic virus 1 - immunology ; Human T-lymphotropic virus 1 - physiology ; Humans ; Japan - epidemiology ; Male ; Middle Aged ; Prevalence ; Sex Factors ; Trans-Activators - immunology</subject><ispartof>The Journal of infectious diseases, 1990-03, Vol.161 (3), p.426-429</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1793-54f5abfd3c42cececdd78ff63fdd85fbd023b26236bb7791fc6df5f7f10695153</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2313123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kashiwagi, Seizaburo</creatorcontrib><creatorcontrib>Kajiyama, Wataru</creatorcontrib><creatorcontrib>Hayashi, Jun</creatorcontrib><creatorcontrib>Noguchi, Akinori</creatorcontrib><creatorcontrib>Nakashima, Koya</creatorcontrib><creatorcontrib>Nomura, Hideyuki</creatorcontrib><creatorcontrib>Ikematsu, Hideyuki</creatorcontrib><creatorcontrib>Sawada, Thkashi</creatorcontrib><creatorcontrib>Kida, Shigeru</creatorcontrib><creatorcontrib>Koide, Atsushi</creatorcontrib><title>Antibody to p40tax Protein of Human T Cell Leukemia Virus 1 and Infectivity</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>To investigate the physiologic significance of antibody to human T cell leukemia virus type 1 (HTLV-1) tax gene product (p40tax), 147 male and 243 female HTLV-1 carriers were examined for anti-p40tax, and 104 carriers were checked for anti-p40tax an average of 5.4 times during an 8-year period. Prevalence of anti-p40tax was significantly higher in female (62.6%) than in male subjects (51.0%; P < .05). Anti-p40tax status did not change in most during the observation period. There were significantly more HTLV-1 carriers among children of anti-p40tax-positive mothers (45.3%) than among those from anti-p4()tax-negative mothers (20.0%; P < .01). However, no significant difference was observed between wives of p40tax-positiveand -negative men. The p40tax antibody may be a marker of relative infectivity of HTLV-, albeit an imperfect one.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>AIDS/HIV</subject><subject>Carrier State - epidemiology</subject><subject>Carrier State - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>HTLV-I Antibodies - analysis</subject><subject>HTLV-I Infections - epidemiology</subject><subject>HTLV-I Infections - immunology</subject><subject>HTLV-I Infections - transmission</subject><subject>Human T-lymphotropic virus 1 - immunology</subject><subject>Human T-lymphotropic virus 1 - physiology</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Sex Factors</subject><subject>Trans-Activators - immunology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNo9kM9PwjAUxxujQUTvXkx68jZo-7aWHgkRIS7qAY3x0nRrm1TYhutm4L93ZIS8wzt8f-S9D0L3lIwpkTDxpTM-TCinYxjHjF-gIU1ARJxTuERDQhiL6FTKa3QTwg8hJAYuBmjAgAJlMEQvs7LxWWUOuKnwLiaN3uP3umqsL3Hl8LItdInXeG63W5zadmMLr_Gnr9uAKdalwavS2bzxf7453KIrp7fB3p32CH0sntbzZZS-Pa_mszTKqZAQJbFLdOYM5DHLbTfGiKlzHJwx08RlhjDIGGfAs0wISV3OjUuccJRwmXTvjdBj37urq9_WhkYVPuTdhbq0VRuUkFx0HUcj6Y15XYVQW6d2tS90fVCUqCM_1fNTHT8FquPXRR5O3W1WWHMOnIB1etTrPjR2f5Z1vVFcgEjU8utbiUVKX4FLJeEfyy97Pg</recordid><startdate>199003</startdate><enddate>199003</enddate><creator>Kashiwagi, Seizaburo</creator><creator>Kajiyama, Wataru</creator><creator>Hayashi, Jun</creator><creator>Noguchi, Akinori</creator><creator>Nakashima, Koya</creator><creator>Nomura, Hideyuki</creator><creator>Ikematsu, Hideyuki</creator><creator>Sawada, Thkashi</creator><creator>Kida, Shigeru</creator><creator>Koide, Atsushi</creator><general>The University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199003</creationdate><title>Antibody to p40tax Protein of Human T Cell Leukemia Virus 1 and Infectivity</title><author>Kashiwagi, Seizaburo ; Kajiyama, Wataru ; Hayashi, Jun ; Noguchi, Akinori ; Nakashima, Koya ; Nomura, Hideyuki ; Ikematsu, Hideyuki ; Sawada, Thkashi ; Kida, Shigeru ; Koide, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1793-54f5abfd3c42cececdd78ff63fdd85fbd023b26236bb7791fc6df5f7f10695153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>AIDS/HIV</topic><topic>Carrier State - epidemiology</topic><topic>Carrier State - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>HTLV-I Antibodies - analysis</topic><topic>HTLV-I Infections - epidemiology</topic><topic>HTLV-I Infections - immunology</topic><topic>HTLV-I Infections - transmission</topic><topic>Human T-lymphotropic virus 1 - immunology</topic><topic>Human T-lymphotropic virus 1 - physiology</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Sex Factors</topic><topic>Trans-Activators - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kashiwagi, Seizaburo</creatorcontrib><creatorcontrib>Kajiyama, Wataru</creatorcontrib><creatorcontrib>Hayashi, Jun</creatorcontrib><creatorcontrib>Noguchi, Akinori</creatorcontrib><creatorcontrib>Nakashima, Koya</creatorcontrib><creatorcontrib>Nomura, Hideyuki</creatorcontrib><creatorcontrib>Ikematsu, Hideyuki</creatorcontrib><creatorcontrib>Sawada, Thkashi</creatorcontrib><creatorcontrib>Kida, Shigeru</creatorcontrib><creatorcontrib>Koide, Atsushi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kashiwagi, Seizaburo</au><au>Kajiyama, Wataru</au><au>Hayashi, Jun</au><au>Noguchi, Akinori</au><au>Nakashima, Koya</au><au>Nomura, Hideyuki</au><au>Ikematsu, Hideyuki</au><au>Sawada, Thkashi</au><au>Kida, Shigeru</au><au>Koide, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibody to p40tax Protein of Human T Cell Leukemia Virus 1 and Infectivity</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1990-03</date><risdate>1990</risdate><volume>161</volume><issue>3</issue><spage>426</spage><epage>429</epage><pages>426-429</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>To investigate the physiologic significance of antibody to human T cell leukemia virus type 1 (HTLV-1) tax gene product (p40tax), 147 male and 243 female HTLV-1 carriers were examined for anti-p40tax, and 104 carriers were checked for anti-p40tax an average of 5.4 times during an 8-year period. Prevalence of anti-p40tax was significantly higher in female (62.6%) than in male subjects (51.0%; P < .05). Anti-p40tax status did not change in most during the observation period. There were significantly more HTLV-1 carriers among children of anti-p40tax-positive mothers (45.3%) than among those from anti-p4()tax-negative mothers (20.0%; P < .01). However, no significant difference was observed between wives of p40tax-positiveand -negative men. The p40tax antibody may be a marker of relative infectivity of HTLV-, albeit an imperfect one.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>2313123</pmid><doi>10.1093/infdis/161.3.426</doi><tpages>4</tpages></addata></record>
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subjects	Adolescent Adult Age Factors Aged Aged, 80 and over AIDS/HIV Carrier State - epidemiology Carrier State - immunology Child Child, Preschool Female HTLV-I Antibodies - analysis HTLV-I Infections - epidemiology HTLV-I Infections - immunology HTLV-I Infections - transmission Human T-lymphotropic virus 1 - immunology Human T-lymphotropic virus 1 - physiology Humans Japan - epidemiology Male Middle Aged Prevalence Sex Factors Trans-Activators - immunology
title	Antibody to p40tax Protein of Human T Cell Leukemia Virus 1 and Infectivity
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