Otologic and laryngologic manifestations of mucopolysaccharidoses after bone marrow transplantation

INTRODUCTION: Children with mucopolysaccharidosis have significant functional impairment of a number of systems because of deposition of glycosaminoglycans. The otolaryngologic system is affected, resulting in conductive and sensorineural hearing loss and voice abnormality. METHOD: Eleven children w...

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Published in:Otolaryngology-head and neck surgery 1998, Vol.118 (1), p.30-36
Main Authors: Papsin, B.C., Vellodi, A., Bailey, C.M., Ratcliff, P.C., Leighton, S.E.J.
Format: Article
Language:English
Subjects:
Bone Marrow Transplantation
Child
Child, Preschool
Female
Hearing Disorders - etiology
Humans
Infant
Male
Mucopolysaccharidoses - complications
Mucopolysaccharidoses - therapy
Otitis Media with Effusion - etiology
Voice Disorders - etiology
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container_title Otolaryngology-head and neck surgery
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creator Papsin, B.C.
Vellodi, A.
Bailey, C.M.
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Leighton, S.E.J.
description INTRODUCTION: Children with mucopolysaccharidosis have significant functional impairment of a number of systems because of deposition of glycosaminoglycans. The otolaryngologic system is affected, resulting in conductive and sensorineural hearing loss and voice abnormality. METHOD: Eleven children who had undergone bone marrow transplantation had their hearing and voices assessed. Unmatched data from patients who had not undergone transplantation were collected for nonstatistical comparison. RESULTS: The hearing loss in children who had undergone bone marrow transplantation was variable but on average was less severe than in the younger children who had not undergone transplantation. The incidence of otitis media with effusion was diminished in the transplanted group. Approximately half had normal voices. DISCUSSION: Diminution of the progression of hearing loss and voice abnormality probably occurs in patients after treatment by bone marrow transplantation. (Otolaryngol Head Neck Surg 1998;118:30-6.)
doi_str_mv 10.1016/S0194-5998(98)70371-7
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The otolaryngologic system is affected, resulting in conductive and sensorineural hearing loss and voice abnormality. METHOD: Eleven children who had undergone bone marrow transplantation had their hearing and voices assessed. Unmatched data from patients who had not undergone transplantation were collected for nonstatistical comparison. RESULTS: The hearing loss in children who had undergone bone marrow transplantation was variable but on average was less severe than in the younger children who had not undergone transplantation. The incidence of otitis media with effusion was diminished in the transplanted group. Approximately half had normal voices. DISCUSSION: Diminution of the progression of hearing loss and voice abnormality probably occurs in patients after treatment by bone marrow transplantation. 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The otolaryngologic system is affected, resulting in conductive and sensorineural hearing loss and voice abnormality. METHOD: Eleven children who had undergone bone marrow transplantation had their hearing and voices assessed. Unmatched data from patients who had not undergone transplantation were collected for nonstatistical comparison. RESULTS: The hearing loss in children who had undergone bone marrow transplantation was variable but on average was less severe than in the younger children who had not undergone transplantation. The incidence of otitis media with effusion was diminished in the transplanted group. Approximately half had normal voices. DISCUSSION: Diminution of the progression of hearing loss and voice abnormality probably occurs in patients after treatment by bone marrow transplantation. 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subjects Bone Marrow Transplantation
Child
Child, Preschool
Female
Hearing Disorders - etiology
Humans
Infant
Male
Mucopolysaccharidoses - complications
Mucopolysaccharidoses - therapy
Otitis Media with Effusion - etiology
Voice Disorders - etiology
title Otologic and laryngologic manifestations of mucopolysaccharidoses after bone marrow transplantation
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