A lymphohistiocytic variant of anaplastic large cell lymphoma with demonstration of the t(2;5)(p23;q35) chromosome translocation

Cytogenetic investigations were performed in a case of a nodal malignant non‐Hodgkin's lymphoma. Histopathological analysis from an involved lymph node as well as from a skin biopsy revealed a lymphohistiocytic variant of CD30‐positive anaplastic large cell lymphoma (ALCL). A t(2;5)(p23;q35) ch...

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Bibliographic Details
Published in:British journal of haematology 1998-01, Vol.100 (1), p.187-190
Main Authors: Ott, German, Bastian, Boris C., Katzenberger, Tiemo, Decoteau, John F., Kalla, Jörg, Rosenwald, Andreas, Weissinger, Florian, Ott, M. Michaela, Kadin, Marshall E., Müller‐Hermelink, Hans K.
Format: Article
Language:English
Subjects:
Adult
anaplastic large cell lymphoma
Biological and medical sciences
Chromosomes, Human, Pair 2 - genetics
Chromosomes, Human, Pair 5 - genetics
cytogenetics
Female
Hematologic and hematopoietic diseases
Humans
Immunohistochemistry
Karyotyping
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
lymphohistiocytic variant
Lymphoma, Large-Cell, Anaplastic - genetics
Medical sciences
NPM/ALK
p80
t(2
5)
Translocation, Genetic
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Summary:Cytogenetic investigations were performed in a case of a nodal malignant non‐Hodgkin's lymphoma. Histopathological analysis from an involved lymph node as well as from a skin biopsy revealed a lymphohistiocytic variant of CD30‐positive anaplastic large cell lymphoma (ALCL). A t(2;5)(p23;q35) chromosome translocation could be observed in all metaphases analysed. This finding was confirmed both by RT‐PCR analysis of the NPM/ALK fusion protein and by positive staining with the p80NPM/ALK antibody. To the best of our knowledge, this is the first report of a t(2;5) documented by classic cytogenetics in the lymphohistiocytic variant of ALCL.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.1998.00531.x