Natural History of Pertussis Antibody in the Infant and Effect on Vaccine Response

To better characterize the transplacental transfer and persistence of pertussis antibodies and their role in the immune response to vaccine, concentrations of pertussis agglutinins and antibodies to lymphocytosis promoting factor (LPF) and filamentous hemagglutinin (FHA) weremeasured in three distin...

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Bibliographic Details
Published in:The Journal of infectious diseases 1990-03, Vol.161 (3), p.487-492
Main Authors: Van Savage, John, Decker, Michael D., Edwards, Kathryn M., Sell, Sarah H., Karzon, David T.
Format: Article
Language:English
Subjects:
Acellular vaccines
Adult
Antibodies
Antibodies, Bacterial - biosynthesis
Bordetella pertussis
Bordetella pertussis - immunology
Bordetella virulence factors
Enzyme linked immunosorbent assay
Female
Fetal Blood - immunology
Half lives
Hemagglutinins - immunology
Humans
Immune response
Immunity, Maternally-Acquired
Immunization
Immunoglobulin G - biosynthesis
Infant
Infant, Newborn
Infants
Major Articles
Pertussis Toxin
Pertussis Vaccine - administration & dosage
Pertussis Vaccine - immunology
Random Allocation
Vaccination
Virulence Factors, Bordetella - immunology
Whooping cough
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Summary:To better characterize the transplacental transfer and persistence of pertussis antibodies and their role in the immune response to vaccine, concentrations of pertussis agglutinins and antibodies to lymphocytosis promoting factor (LPF) and filamentous hemagglutinin (FHA) weremeasured in three distinct groups of serum. Transplacental pertussis IgG antibody concentrations in newborns were found to be comparable to corresponding maternal concentrations and to decline with a half-life of ∼6 weeks. By the age of 4 months, most infants had no detectable.antibodies to LPF or FHA. Higher concentrations of maternally derived antibody to LPF were associated with a significantly weaker antibody response to conventional vaccine. In contrast, acellular vaccine stimulated superior antibody production, regardless of antecedent concentrations of antibody to LPF. The data support continuation of the current schedule of pertussis immunization and further efforts to develop an acellular vaccine for use in young infants.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/161.3.487