Epstein-Barr Virus-Induced T Cell Lymphoma in Solid Organ Transplant Recipients

Epstein-Barr virus (EBV) infection in transplant recipients can lead to lymphomas termed posttransplantation lymphoproliferative disorders (PTLDs). Most PTLDs are malignancies of B lymphocytes and are linked to EBV infection, but the rare T lymphocyte PTLDs have been inconsistently linked to EBV inf...

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Bibliographic Details
Published in:Clinical infectious diseases 1998-01, Vol.26 (1), p.180-182
Main Authors: Dockrell, David H., Strickler, John G., Paya, Carlos V.
Format: Article
Language:English
Subjects:
B lymphocytes
Biological and medical sciences
Biopsies
Cellular immunity
Epstein Barr virus infections
Heart Transplantation - adverse effects
Hematologic and hematopoietic diseases
Herpesviridae Infections - complications
Herpesvirus 4, Human
Humans
Kidney Transplantation - adverse effects
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Liver Transplantation - adverse effects
Lymphoma
Lymphoma, T-Cell - etiology
Lymphoproliferative disorders
Male
Medical sciences
Middle Aged
T cell lymphoma
T lymphocytes
Transplantation
Tumor Virus Infections - complications
Viruses
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Summary:Epstein-Barr virus (EBV) infection in transplant recipients can lead to lymphomas termed posttransplantation lymphoproliferative disorders (PTLDs). Most PTLDs are malignancies of B lymphocytes and are linked to EBV infection, but the rare T lymphocyte PTLDs have been inconsistently linked to EBV infection. Although the B lymphocyte is the main host cell of EBV, it has been suggested that T lymphocytes may also become infected by EBV. A review of EBV-induced PTLDs at our institution identified one of 61 cases that was restricted to T lymphocytes. Of 36 cases of T cell PTLD identified through a literature review, 21 were investigated for the presence of EBV, and eight (38%) were documented to be EBV-induced. We compared the features of EBV-positive and EBV-negative T cell PTLDs and concluded that cases of EBV-positive T cell PTLD have some distinctive clinical features.
ISSN:1058-4838
1537-6591
DOI:10.1086/516269