Calcitonin gene-related peptide is a depressor in subtotal nephrectomy hypertension

We previously demonstrated that the neuronal expression of calcitonin gene-related peptide (CGRP), a potent vasodilator, is increased in deoxycorticosterone-salt-induced hypertension where it acts as a compensatory vasodilator to attenuate the elevated blood pressure. To determine whether CGRP is pl...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1998, Vol.31 (1), p.391-396
Main Authors: SUPOWIT, S. C, HUAWEI ZHAO, HALLMAN, D. M, DIPETTE, D. J
Format: Article
Language:English
Subjects:
Animals
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - drug effects
Blood Pressure - physiology
Calcitonin Gene-Related Peptide - biosynthesis
Calcitonin Gene-Related Peptide - pharmacology
Calcitonin Gene-Related Peptide Receptor Antagonists
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Ganglia, Spinal - metabolism
Humans
Hypertension, Renovascular - physiopathology
Male
Medical sciences
Nephrectomy
Neurons - metabolism
Peptide Fragments - pharmacology
Rats
Rats, Sprague-Dawley
RNA, Messenger - biosynthesis
Sodium, Dietary
Transcription, Genetic
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Summary:We previously demonstrated that the neuronal expression of calcitonin gene-related peptide (CGRP), a potent vasodilator, is increased in deoxycorticosterone-salt-induced hypertension where it acts as a compensatory vasodilator to attenuate the elevated blood pressure. To determine whether CGRP is playing a similar role in subtotal nephrectomy-salt-induced hypertension, hypertension was induced in Sprague-Dawley rats (n=6) by subtotal nephrectomy and 1.0% saline drinking water. Control rats (n=6) were sham operated and given tap water to drink. CGRP(8-37), a CGRP receptor antagonist, was used to assess the hemodynamic role of CGRP in this setting. CGRP mRNA and peptide levels in dorsal root ganglia were also determined. Three weeks after either protocol, all rats had intravenous (for drug administration) and arterial (for continuous mean arterial pressure monitoring) catheters surgically placed and were studied in the conscious, unrestrained state. CGRP(8-37) (3.2 or 6.4 x 10(4) pmol/L in 0.1 mL saline) and vehicle were administered intravenously to all rats. Baseline mean arterial pressure was higher in the subtotal nephrectomized rats compared with the controls (173+/-5 versus 113+/-5 mm Hg, P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.31.1.391