Carotid wall viscosity increase is related to intima-media thickening in hypertensive patients

Increases in arterial wall viscosity and intima-media thickness (IMT) were found in hypertensive patients. Because smooth muscle cells are responsible for the viscous behavior of the arterial wall and they are involved in the process of thickening of the intima-media complex, this study evaluates th...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1998, Vol.31 (1), p.534-539
Main Authors: ARMENTANO, R. L, GRAF, S, BARRA, J. G, VELIKOVSKY, G, BAGLIVO, H, SANCHEZ, R, SIMON, A, PICHEL, R. H, LEVENSON, J
Format: Article
Language:English
Subjects:
Algorithms
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Carotid Arteries - diagnostic imaging
Carotid Arteries - physiopathology
Echocardiography
Experimental diseases
Humans
Hypertension - diagnostic imaging
Hypertension - physiopathology
Medical sciences
Middle Aged
Reference Values
Regression Analysis
Reproducibility of Results
Tunica Intima - diagnostic imaging
Tunica Intima - physiopathology
Tunica Media - diagnostic imaging
Tunica Media - physiopathology
Viscosity
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Summary:Increases in arterial wall viscosity and intima-media thickness (IMT) were found in hypertensive patients. Because smooth muscle cells are responsible for the viscous behavior of the arterial wall and they are involved in the process of thickening of the intima-media complex, this study evaluates the relationship between carotid thickness and wall viscosity. The simultaneous and noninvasive assessment of the intima-media complex and arterial diameter waveform was performed using high-resolution ultrasonography. This technique was contrasted against sonomicrometry in sheep, showing that the waveforms obtained by both methods were similar. The common carotid arteries of 11 normotensive subjects (NTA) and 11 patients with mild to moderate essential hypertension (HTA) were measured noninvasively by using tonometry and an automatic densitometric analysis of B-mode images to obtain IMT and instantaneous pressure and diameter loops. A viscoelastic model was used to derive the wall viscosity index (eta) using the hysteresis loop elimination criteria. In NTA, eta was 2.73+/-1.66 (mm Hg x s/mm) and IMT was 0.58+/-0.08 (mm), whereas in HTA, eta was 5.91+/-2.34 (P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.31.1.534