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An anatomic study of the rat larynx: Establishing the rat model for neuromuscular function
The gross and microscopic anatomy of the rat larynx was studied with particular attention to myology and neuromuscular structures to further validate it as a model to evaluate morphologic and functional changes induced by botulinum injection. A laryngeal alar cartilage (LAlC), alar cricoarytenoid (A...
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Published in: | Otolaryngology-head and neck surgery 1998, Vol.118 (1), p.74-81 |
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container_title | Otolaryngology-head and neck surgery |
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creator | Inagi, Katsuhide Schultz, Edward Ford, Charles N. |
description | The gross and microscopic anatomy of the rat larynx was studied with particular attention to myology and neuromuscular structures to further validate it as a model to evaluate morphologic and functional changes induced by botulinum injection. A laryngeal alar cartilage (LAlC), alar cricoarytenoid (ACA) muscle, and a superior cricoarytenoid muscle (SCA) were identified as anatomic structures not previously described. Two portions (medial and lateral) of the thyroarytenoid muscle (TA) were distinguished. The function of the ACA was suggested to be similar to the aryepiglottis muscle in humans and the function of the SCA was suggested to be similar to the human interarytenoid muscle. The predominant pattern of motor endplate (MEP) distribution in rat laryngeal muscles (posterior cricoarytenoid, lateral cricoarytenoid, cricothyroid, and SCA) was to have MEPs concentrated mostly at the midbelly of muscle where they were distributed throughout the cross-sectional area of the midbelly. The TA and ACA differed from this pattern. The lateral TA had MEPs concentrated at the anterior third of its belly and those of the medial TA were located at the midbelly. Motor endplates in the ACA were located mostly at the posterior portion of muscle. Muscle fiber-typing showed subtle differences between the intrinsic laryngeal muscles. Fast fibers were predominant in the rat laryngeal muscles. This study supports the expanded use of rats in studies of laryngeal neuromuscular function and disease in humans. (Otolaryngol Head Neck Surg 1998;118:74-81.) |
doi_str_mv | 10.1016/S0194-5998(98)70378-X |
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A laryngeal alar cartilage (LAlC), alar cricoarytenoid (ACA) muscle, and a superior cricoarytenoid muscle (SCA) were identified as anatomic structures not previously described. Two portions (medial and lateral) of the thyroarytenoid muscle (TA) were distinguished. The function of the ACA was suggested to be similar to the aryepiglottis muscle in humans and the function of the SCA was suggested to be similar to the human interarytenoid muscle. The predominant pattern of motor endplate (MEP) distribution in rat laryngeal muscles (posterior cricoarytenoid, lateral cricoarytenoid, cricothyroid, and SCA) was to have MEPs concentrated mostly at the midbelly of muscle where they were distributed throughout the cross-sectional area of the midbelly. The TA and ACA differed from this pattern. The lateral TA had MEPs concentrated at the anterior third of its belly and those of the medial TA were located at the midbelly. Motor endplates in the ACA were located mostly at the posterior portion of muscle. Muscle fiber-typing showed subtle differences between the intrinsic laryngeal muscles. Fast fibers were predominant in the rat laryngeal muscles. This study supports the expanded use of rats in studies of laryngeal neuromuscular function and disease in humans. 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A laryngeal alar cartilage (LAlC), alar cricoarytenoid (ACA) muscle, and a superior cricoarytenoid muscle (SCA) were identified as anatomic structures not previously described. Two portions (medial and lateral) of the thyroarytenoid muscle (TA) were distinguished. The function of the ACA was suggested to be similar to the aryepiglottis muscle in humans and the function of the SCA was suggested to be similar to the human interarytenoid muscle. The predominant pattern of motor endplate (MEP) distribution in rat laryngeal muscles (posterior cricoarytenoid, lateral cricoarytenoid, cricothyroid, and SCA) was to have MEPs concentrated mostly at the midbelly of muscle where they were distributed throughout the cross-sectional area of the midbelly. The TA and ACA differed from this pattern. The lateral TA had MEPs concentrated at the anterior third of its belly and those of the medial TA were located at the midbelly. Motor endplates in the ACA were located mostly at the posterior portion of muscle. Muscle fiber-typing showed subtle differences between the intrinsic laryngeal muscles. Fast fibers were predominant in the rat laryngeal muscles. This study supports the expanded use of rats in studies of laryngeal neuromuscular function and disease in humans. (Otolaryngol Head Neck Surg 1998;118:74-81.)</description><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Laryngeal Muscles - anatomy & histology</subject><subject>Laryngeal Muscles - innervation</subject><subject>Laryngeal Nerves - anatomy & histology</subject><subject>Larynx - anatomy & histology</subject><subject>Male</subject><subject>Motor Endplate - anatomy & histology</subject><subject>Myosins - classification</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqNkF1r1TAYx4Mo8zj9CINciV50JmmbNILIHHsRhrvYhOFNSJOnW0abbEmjnm9vzno4txMCCfxfnjw_hA4oOaSE8k9XhMqmaqXsPsjuoyC16KqbF2hFiRQV76h4iVY7y2v0JqV7QgjnQuyhPdm0pKvZCv068lh7PYfJGZzmbNc4DHi-Axz1jEcd1_7vZ3ySZt2PLt05f7sTp2BhxEOI2EOOYcrJ5BLAQ_ZmdsG_Ra8GPSZ4t7330c_Tk-vj8-ri8uz78dFFZVpWNxXreTuQuieipVrYHnrOGklIeWlSm8bqzRbECkbrrq47sF0rO8aEhQEoI_U-er_0PsTwmCHNanLJwDhqDyEnJSQXXDBejO1iNDGkFGFQD9FNZUVFidowVU9M1QaYKueJqbopuYPtgNxPYHepLcSif1n0P26E9f-VqsvzH99OGZeiKXm25JO-BXUfcvSF17Of-rqEoKD97SCqZBx4A9ZFMLOywT3T8A-6xaga</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Inagi, Katsuhide</creator><creator>Schultz, Edward</creator><creator>Ford, Charles N.</creator><general>Mosby, Inc</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>1998</creationdate><title>An anatomic study of the rat larynx: Establishing the rat model for neuromuscular function</title><author>Inagi, Katsuhide ; Schultz, Edward ; Ford, Charles N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5234-2b65f03b0751a7dbeb624900dbea03c4da01940d72138338ed8598227defe1203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Laryngeal Muscles - anatomy & histology</topic><topic>Laryngeal Muscles - innervation</topic><topic>Laryngeal Nerves - anatomy & histology</topic><topic>Larynx - anatomy & histology</topic><topic>Male</topic><topic>Motor Endplate - anatomy & histology</topic><topic>Myosins - classification</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inagi, Katsuhide</creatorcontrib><creatorcontrib>Schultz, Edward</creatorcontrib><creatorcontrib>Ford, Charles N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inagi, Katsuhide</au><au>Schultz, Edward</au><au>Ford, Charles N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An anatomic study of the rat larynx: Establishing the rat model for neuromuscular function</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>1998</date><risdate>1998</risdate><volume>118</volume><issue>1</issue><spage>74</spage><epage>81</epage><pages>74-81</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>The gross and microscopic anatomy of the rat larynx was studied with particular attention to myology and neuromuscular structures to further validate it as a model to evaluate morphologic and functional changes induced by botulinum injection. A laryngeal alar cartilage (LAlC), alar cricoarytenoid (ACA) muscle, and a superior cricoarytenoid muscle (SCA) were identified as anatomic structures not previously described. Two portions (medial and lateral) of the thyroarytenoid muscle (TA) were distinguished. The function of the ACA was suggested to be similar to the aryepiglottis muscle in humans and the function of the SCA was suggested to be similar to the human interarytenoid muscle. The predominant pattern of motor endplate (MEP) distribution in rat laryngeal muscles (posterior cricoarytenoid, lateral cricoarytenoid, cricothyroid, and SCA) was to have MEPs concentrated mostly at the midbelly of muscle where they were distributed throughout the cross-sectional area of the midbelly. The TA and ACA differed from this pattern. The lateral TA had MEPs concentrated at the anterior third of its belly and those of the medial TA were located at the midbelly. Motor endplates in the ACA were located mostly at the posterior portion of muscle. Muscle fiber-typing showed subtle differences between the intrinsic laryngeal muscles. Fast fibers were predominant in the rat laryngeal muscles. This study supports the expanded use of rats in studies of laryngeal neuromuscular function and disease in humans. (Otolaryngol Head Neck Surg 1998;118:74-81.)</abstract><cop>Los Angeles, CA</cop><pub>Mosby, Inc</pub><pmid>9450832</pmid><doi>10.1016/S0194-5998(98)70378-X</doi><tpages>8</tpages></addata></record> |
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subjects | Animals Disease Models, Animal Laryngeal Muscles - anatomy & histology Laryngeal Muscles - innervation Laryngeal Nerves - anatomy & histology Larynx - anatomy & histology Male Motor Endplate - anatomy & histology Myosins - classification Rats Rats, Sprague-Dawley |
title | An anatomic study of the rat larynx: Establishing the rat model for neuromuscular function |
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