Glutamate receptors on postganglionic sympathetic axons

The present study demonstrates that approximately 36% of postganglionic sympathetic axons in gray rami express receptors for the N-methyl-d-aspartate receptor 1 subunit of the N-methyl-d-aspartate receptor and 10% express the glutamate receptor 1 subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazole...

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Bibliographic Details
Published in:Neuroscience 1998, Vol.83 (2), p.601-605
Main Authors: Carlton, S.M, Chung, K, Ding, Z, Coggeshall, R.E
Format: Article
Language:English
Subjects:
AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Animals
Axons - metabolism
Axons - ultrastructure
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Ganglia, Sympathetic - cytology
Ganglia, Sympathetic - metabolism
Ganglia, Sympathetic - ultrastructure
GluR, glutamate receptor
Immunohistochemistry
Male
MK-801, dizocilpine maleate
NA, noraradrenaline
NGS, normal goat serum
NMDA
NMDA, N-methyl-D-aspartate
NMDAR1, N-methyl-D-aspartate receptor subunit 1
nociception
non-NMDA
pain
PB, phosphate buffer
Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ
Presynaptic Terminals - metabolism
Presynaptic Terminals - ultrastructure
Rats
Rats, Sprague-Dawley
Receptors, AMPA - metabolism
Receptors, Glutamate - metabolism
Reflex - physiology
Sympathetic Fibers, Postganglionic - metabolism
Sympathetic Fibers, Postganglionic - ultrastructure
Vertebrates: nervous system and sense organs
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Summary:The present study demonstrates that approximately 36% of postganglionic sympathetic axons in gray rami express receptors for the N-methyl-d-aspartate receptor 1 subunit of the N-methyl-d-aspartate receptor and 10% express the glutamate receptor 1 subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor. If these receptors are active, glutamate released from primary afferent terminals could activate these receptors resulting in the release of noradrenaline and other substances from postganglionic sympathetic neurons. This interaction would constitute a non-synaptic, sensory-sympathetic, peripheral reflex that might be important in local vascular control and in pain states that have a sympathetic component.
ISSN:0306-4522
1873-7544
DOI:10.1016/S0306-4522(97)00406-5