The effects of oxytetracycline on Theileria parva in vitro

When bovine peripheral blood leucocytes were infected with Theileria parva sporozoites, immediate treatment with oxytetracycline (OTC) inhibited the development of sporozoites to mature schizonts. The extent of inhibition was dependent on drug concentration and duration of treatment. Concentrations...

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Bibliographic Details
Published in:Parasitology 1990-02, Vol.100 (1), p.11-17
Main Author: Spooner, P. R.
Format: Article
Language:English
Subjects:
Animal protozoal diseases
Animals
Apicomplexa - drug effects
Apicomplexa - growth & development
Biological and medical sciences
Cattle
Cell Division - drug effects
Cell Line
Cells, Cultured
Chlortetracycline - pharmacology
Clone Cells
Dose-Response Relationship, Drug
drug effects
East Coast fever
immunization
in vitro
Infectious diseases
lymphocyte proliferation
lymphocytes
Medical sciences
oxytetracycline
Oxytetracycline - pharmacology
Parasitic diseases
pathogenicity
Protozoal diseases
Tetracycline - pharmacology
tetracyclines
Theileria parva
Theileriasis - parasitology
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Summary:When bovine peripheral blood leucocytes were infected with Theileria parva sporozoites, immediate treatment with oxytetracycline (OTC) inhibited the development of sporozoites to mature schizonts. The extent of inhibition was dependent on drug concentration and duration of treatment. Concentrations of 5 μg/ml OTC, or higher, for 8 days completely inhibited the establishment of schizonts and their ability to transform host cells. A cytostatic effect on schizont-infected cell lines was found with three tetracyclines and was also demonstrated on uninfected lymphoblasts. The parasites were found to be sensitive t OTC during development to schizonts, but when mature and established within host cells, schizonts were not demonstrably affected. The infectivity of sporozoites and the binding of sporozoites to lymphocytes were not directly inhibited by OTC. The results may explain the action of tetracyclines when used prophylactically during immunization against East Coast fever, and also the reasons for the ineffectiveness of these drugs when used therapeutically during patent disease.
ISSN:0031-1820
1469-8161
DOI:10.1017/S0031182000060066