Relation of Ultrasonic Tissue Characterization With Integrated Backscatter to Contractile Reserve in Chronic Left Ventricular Ischemic Dysfunction

Previous studies have shown that viable but stunned myocardium displays contractile reserve and exhibits cardiac cycle-dependent variations of integrated backscatter, whereas infarcted myocardium does not. The present study was designed to evaluate whether integrated backscatter imaging could be use...

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Bibliographic Details
Published in:The American journal of cardiology 1998, Vol.81 (1), p.68-74
Main Authors: Pasquet, Agnès, D’Hondt, Anne-Marie, Melin, Jacques A, Vanoverschelde, Jean-Louis J
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Cardiology. Vascular system
Cardiotonic Agents
Cardiovascular disease
Case-Control Studies
Chronic Disease
Coronary Disease - complications
Coronary heart disease
Dobutamine
Echocardiography, Transesophageal
Female
Heart
Humans
Male
Medical sciences
Middle Aged
Myocardial Contraction
Periodicity
Recruitment, Neurophysiological
Severity of Illness Index
Ultrasonic imaging
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - etiology
Ventricular Dysfunction, Left - physiopathology
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Summary:Previous studies have shown that viable but stunned myocardium displays contractile reserve and exhibits cardiac cycle-dependent variations of integrated backscatter, whereas infarcted myocardium does not. The present study was designed to evaluate whether integrated backscatter imaging could be useful in identifying segments with recruitable inotropic reserve in patients with chronic left ventricular (LV) ischemic dysfunction. We studied 15 patients (mean age 59 ± 10 years) with chronic coronary artery disease, anterior or inferior wall dysfunction, and depressed LV ejection fraction (35 ± 12%), and 6 noncardiac control subjects (mean age 49 ± 18 years). Cardiac cycle-dependent variations of integrated backscatter were measured in anterior and inferior segments during transesophageal echocardiography and compared with the contractile response (% wall thickening) of these segments to low doses of dobutamine (5 to 10 μg/kg/min). The average magnitude of cardiac cycle-dependent variations of integrated backscatter was greater among normally contracting segments of both patients and controls (5.67 ± 0.88 and 5.64 ± 2.26 dB, respectively, p = NS) than among dysfunctional segments (2.77 ± 3.05 dB, p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(97)00861-8