Localization of protein kinase C-β-like immunoreactivity in the rat dorsal root ganglion

The localization of protein kinase C-β-like immunoreactivity (PKC-β-LI) was studied in the rat dorsal root ganglion (DRG) using an antibody specific for a peptide sequence common to the β 1- and β 2-subtypes. PKC-β-LI was seen in 45% of neuronal cell bodies and in nerve fibers, which were mostly mye...

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Bibliographic Details
Published in:Neuroscience research 1990-02, Vol.7 (4), p.381-384
Main Authors: Roivainen, Reina, Koistinaho, Jari, Hervonen, Antti
Format: Article
Language:English
Subjects:
Animals
Dorsal root ganglion
Enzyme subtypes
Ganglia, Spinal - cytology
Ganglia, Spinal - enzymology
Immunohistochemistry
Male
Protein kinase C
Protein Kinase C - metabolism
Rat
Rats
Rats, Inbred Strains
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Summary:The localization of protein kinase C-β-like immunoreactivity (PKC-β-LI) was studied in the rat dorsal root ganglion (DRG) using an antibody specific for a peptide sequence common to the β 1- and β 2-subtypes. PKC-β-LI was seen in 45% of neuronal cell bodies and in nerve fibers, which were mostly myelinated. The PKC-β-LI-containing cell bodies had a diameter significantly larger than the unlabeled cell bodies. The results suggest that PKC-β is a PKC subtype involved in cell surface signal transduction in the subpopulation of large DRG neurons.
ISSN:0168-0102
1872-8111
DOI:10.1016/0168-0102(90)90012-4