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Selected pharmacodynamic and biochemical properties of selenonium choline
1. 1. Five minutes after intravenous administration of 50 mg/kg of the novel choline analogue selenonium choline [(CH 3) 2Se +CH 2CH 2OH, SeCh], only 8% of the administered dose was accounted for in blood, brain, liver, heart, and kidney tissues. 2. 2. SeCh was acetylated in vivo to acetylselenonium...
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| Published in: | General pharmacology 1998, Vol.30 (1), p.95-101 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 101 |
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| container_start_page | 95 |
| container_title | General pharmacology |
| container_volume | 30 |
| creator | Khatri, J.N. Silks, L.A. Kosh, J.W. |
| description | 1.
1. Five minutes after intravenous administration of 50 mg/kg of the novel choline analogue selenonium choline [(CH
3)
2Se
+CH
2CH
2OH, SeCh], only 8% of the administered dose was accounted for in blood, brain, liver, heart, and kidney tissues.
2.
2. SeCh was acetylated
in vivo to acetylselenonium choline (ASeCh) in all of the tissues examined.
3.
3. During postmortem incubation, brain concentrations of SeCh and ASeCh increased to 535% and to 425%, respectively.
4.
4.
K
m and
V
max values for the phosphorylation of SeCh by choline kinase were higher and lower, respectively, compared to the phosphorylation of choline.
5.
5. Acetylation of SeCh was described with
K
m and
V
max values that were both higher than the values for Ch.
6.
6. The data suggest that SeCh is phosphorylated and incorporated into various lipids in brain tissue, and is acetylated to ASeCh by both nonneural and neural tissues. |
| doi_str_mv | 10.1016/S0306-3623(97)00080-3 |
| format | article |
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1. Five minutes after intravenous administration of 50 mg/kg of the novel choline analogue selenonium choline [(CH
3)
2Se
+CH
2CH
2OH, SeCh], only 8% of the administered dose was accounted for in blood, brain, liver, heart, and kidney tissues.
2.
2. SeCh was acetylated
in vivo to acetylselenonium choline (ASeCh) in all of the tissues examined.
3.
3. During postmortem incubation, brain concentrations of SeCh and ASeCh increased to 535% and to 425%, respectively.
4.
4.
K
m and
V
max values for the phosphorylation of SeCh by choline kinase were higher and lower, respectively, compared to the phosphorylation of choline.
5.
5. Acetylation of SeCh was described with
K
m and
V
max values that were both higher than the values for Ch.
6.
6. The data suggest that SeCh is phosphorylated and incorporated into various lipids in brain tissue, and is acetylated to ASeCh by both nonneural and neural tissues.</description><identifier>ISSN: 0306-3623</identifier><identifier>EISSN: 1879-0011</identifier><identifier>DOI: 10.1016/S0306-3623(97)00080-3</identifier><identifier>PMID: 9457488</identifier><identifier>CODEN: GEPHDP</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acetylation ; Animals ; Biochemistry and metabolism ; Biological and medical sciences ; Brain - metabolism ; Central nervous system ; Choline - analogs & derivatives ; Choline - metabolism ; Choline - pharmacokinetics ; cholinergic ; false neurotransmitter ; Fundamental and applied biological sciences. Psychology ; Male ; Mice ; Mice, Inbred ICR ; Phosphorylation ; postmortem ; Selenium ; Selenium - metabolism ; Selenium - pharmacokinetics ; selenonium choline ; Tissue Distribution ; Vertebrates: nervous system and sense organs</subject><ispartof>General pharmacology, 1998, Vol.30 (1), p.95-101</ispartof><rights>1998</rights><rights>1998 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c337t-2da90ce0045bf6e2494a6781798f323d868d1eeb41df1e76f9201940eb9066703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2127384$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9457488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khatri, J.N.</creatorcontrib><creatorcontrib>Silks, L.A.</creatorcontrib><creatorcontrib>Kosh, J.W.</creatorcontrib><title>Selected pharmacodynamic and biochemical properties of selenonium choline</title><title>General pharmacology</title><addtitle>Gen Pharmacol</addtitle><description>1.
1. Five minutes after intravenous administration of 50 mg/kg of the novel choline analogue selenonium choline [(CH
3)
2Se
+CH
2CH
2OH, SeCh], only 8% of the administered dose was accounted for in blood, brain, liver, heart, and kidney tissues.
2.
2. SeCh was acetylated
in vivo to acetylselenonium choline (ASeCh) in all of the tissues examined.
3.
3. During postmortem incubation, brain concentrations of SeCh and ASeCh increased to 535% and to 425%, respectively.
4.
4.
K
m and
V
max values for the phosphorylation of SeCh by choline kinase were higher and lower, respectively, compared to the phosphorylation of choline.
5.
5. Acetylation of SeCh was described with
K
m and
V
max values that were both higher than the values for Ch.
6.
6. The data suggest that SeCh is phosphorylated and incorporated into various lipids in brain tissue, and is acetylated to ASeCh by both nonneural and neural tissues.</description><subject>Acetylation</subject><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Central nervous system</subject><subject>Choline - analogs & derivatives</subject><subject>Choline - metabolism</subject><subject>Choline - pharmacokinetics</subject><subject>cholinergic</subject><subject>false neurotransmitter</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Phosphorylation</subject><subject>postmortem</subject><subject>Selenium</subject><subject>Selenium - metabolism</subject><subject>Selenium - pharmacokinetics</subject><subject>selenonium choline</subject><subject>Tissue Distribution</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-3623</issn><issn>1879-0011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LJDEQhsPiouO4P0Hog8h6aLeSdOfjJCJ-wcAeXM8hnVQzke7OmMwI8-83OsNcPRVFPW9V8RByTuGaAhV_XoCDqLlg_LeWVwCgoOY_yIwqqWsASo_I7ICckNOc3wrEWsaOybFuWtkoNSPPLzigW6OvVkubRuui3052DK6yk6-6EN0SS2eHapXiCtM6YK5iX-USm-IUNmPllnEIE56Rn70dMv7a1zl5fbj_d_dUL_4-Pt_dLmrHuVzXzFsNDgGatusFskY3VkhFpVY9Z9wroTxF7Brqe4pS9JoB1Q1gp0EICXxOLnd7y0PvG8xrM4bscBjshHGTjdRCUdqyArY70KWYc8LerFIYbdoaCuZToflSaD79GC3Nl0LDS-58f2DTjegPqb2zMr_Yz20uYvpkJxfyAWOUSa6agt3sMCwyPgImk13AyaEPqRg3PoZvHvkPdpKM2Q</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Khatri, J.N.</creator><creator>Silks, L.A.</creator><creator>Kosh, J.W.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Selected pharmacodynamic and biochemical properties of selenonium choline</title><author>Khatri, J.N. ; Silks, L.A. ; Kosh, J.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-2da90ce0045bf6e2494a6781798f323d868d1eeb41df1e76f9201940eb9066703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acetylation</topic><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Central nervous system</topic><topic>Choline - analogs & derivatives</topic><topic>Choline - metabolism</topic><topic>Choline - pharmacokinetics</topic><topic>cholinergic</topic><topic>false neurotransmitter</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Phosphorylation</topic><topic>postmortem</topic><topic>Selenium</topic><topic>Selenium - metabolism</topic><topic>Selenium - pharmacokinetics</topic><topic>selenonium choline</topic><topic>Tissue Distribution</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>online_resources</toplevel><creatorcontrib>Khatri, J.N.</creatorcontrib><creatorcontrib>Silks, L.A.</creatorcontrib><creatorcontrib>Kosh, J.W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>General pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khatri, J.N.</au><au>Silks, L.A.</au><au>Kosh, J.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selected pharmacodynamic and biochemical properties of selenonium choline</atitle><jtitle>General pharmacology</jtitle><addtitle>Gen Pharmacol</addtitle><date>1998</date><risdate>1998</risdate><volume>30</volume><issue>1</issue><spage>95</spage><epage>101</epage><pages>95-101</pages><issn>0306-3623</issn><eissn>1879-0011</eissn><coden>GEPHDP</coden><abstract>1.
1. Five minutes after intravenous administration of 50 mg/kg of the novel choline analogue selenonium choline [(CH
3)
2Se
+CH
2CH
2OH, SeCh], only 8% of the administered dose was accounted for in blood, brain, liver, heart, and kidney tissues.
2.
2. SeCh was acetylated
in vivo to acetylselenonium choline (ASeCh) in all of the tissues examined.
3.
3. During postmortem incubation, brain concentrations of SeCh and ASeCh increased to 535% and to 425%, respectively.
4.
4.
K
m and
V
max values for the phosphorylation of SeCh by choline kinase were higher and lower, respectively, compared to the phosphorylation of choline.
5.
5. Acetylation of SeCh was described with
K
m and
V
max values that were both higher than the values for Ch.
6.
6. The data suggest that SeCh is phosphorylated and incorporated into various lipids in brain tissue, and is acetylated to ASeCh by both nonneural and neural tissues.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9457488</pmid><doi>10.1016/S0306-3623(97)00080-3</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-3623 |
| ispartof | General pharmacology, 1998, Vol.30 (1), p.95-101 |
| issn | 0306-3623 1879-0011 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79681152 |
| source | ScienceDirect Freedom Collection |
| subjects | Acetylation Animals Biochemistry and metabolism Biological and medical sciences Brain - metabolism Central nervous system Choline - analogs & derivatives Choline - metabolism Choline - pharmacokinetics cholinergic false neurotransmitter Fundamental and applied biological sciences. Psychology Male Mice Mice, Inbred ICR Phosphorylation postmortem Selenium Selenium - metabolism Selenium - pharmacokinetics selenonium choline Tissue Distribution Vertebrates: nervous system and sense organs |
| title | Selected pharmacodynamic and biochemical properties of selenonium choline |
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