PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily

An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular junctions. This antibody identified a complementary DNA clone from...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1990-03, Vol.247 (4947), p.1219-1222
Main Authors: Newman, Peter J., Berndt, Michael C., Gorski, Jack, White, Gilbert C., Lyman, Suzanne, Paddock, Cathy, Muller, William A.
Format: Article
Language:English
Subjects:
Activation
Amino Acid Sequence
Amino acids
Antibodies
Antibodies, Monoclonal
Antigen-antibody reactions
Antigens
Antigens, Differentiation, Myelomonocytic - genetics
Biological and medical sciences
Blood platelets
Cell adhesion
Cell adhesion molecules
Cell Adhesion Molecules - genetics
Cloning
Cloning, Molecular
Complementary DNA
DNA - analysis
Endothelial cells
Endothelium, Vascular - analysis
Endothelium, Vascular - immunology
Epithelial cells
Epitopes - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
gene families
Genes, Immunoglobulin
Genetic aspects
Genetics
Glycoproteins
Humans
Immunoblotting
Immunoglobulins
Immunohematology
Immunosorbent Techniques
Medical research
Membrane glycoproteins
Molecular Sequence Data
Molecules
Physiological aspects
Platelet activation
Platelet Endothelial Cell Adhesion Molecule-1
Platelet immunology
Platelet Membrane Glycoproteins - immunology
Platelets
Protein Conformation
Proteins
Receptors
Repetitive Sequences, Nucleic Acid
Sequence Homology, Nucleic Acid
Signal Transduction
Viral antibodies
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Description
Summary:An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular junctions. This antibody identified a complementary DNA clone from an endothelial cell library. The 130-kilodalton translated sequence contained six extracellular immunoglobulin (Ig)-like domains and was most similar to the cell adhesion molecule (CAM) subgroup of the Ig superfamily. This is the only known member of the CAM family on platelets. Its cell surface distribution suggests participation in cellular recognition events.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1690453