Frequent allelic loss on chromosomes 4q and 16q associated with human hepatocellular carcinoma in Taiwan

To define the critical region of liver-specific tumor suppressor genes in human hepatocellular carcinoma (HCC), we analyzed 30 cases of hepatocellular carcinoma using nine 4q and six 16q microsatellite polymorphic DNA markers. We observed one major common deleted region which was flanked by D4S175–D...

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Bibliographic Details
Published in:Cancer letters 1998-01, Vol.123 (1), p.1-6
Main Authors: Chou, Yah-Huei Wu, Chung, Kuo-Chen, Jeng, Long-Bin, Chen, Tse-Ching, Liaw, Yun-Fan
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Hepatocellular - genetics
Chromosome Mapping
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 4
Gastroenterology. Liver. Pancreas. Abdomen
Genes, Tumor Suppressor
Human hepatocellular carcinoma
Humans
Liver Neoplasms - genetics
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Loss of Heterozygosity
Medical sciences
Microsatellite analysis
Microsatellite Repeats
Taiwan
Tumors
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Summary:To define the critical region of liver-specific tumor suppressor genes in human hepatocellular carcinoma (HCC), we analyzed 30 cases of hepatocellular carcinoma using nine 4q and six 16q microsatellite polymorphic DNA markers. We observed one major common deleted region which was flanked by D4S175–D4S1625 and there may be two tumor suppressor genes on chromosome 16q associated with HCC. An extensive study of allelotyping of human HCC was therefore carried out in the candidate region on arms of chromosome 4q with additional tumor tissues and more informative microsatellite DNA markers. These data imply that at least one putative tumor suppressor gene is located in the human chromosome 4q26-q27 region and provides very useful information for further construction of a long-range physical restriction map and thereafter cloning of the putative tumor suppressor gene.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(97)00276-0