Localization of the Human CXC Chemokine Subfamily on the Long Arm of Chromosome 4 Using Radiation Hybrids

All 12 of the human CXC chemokine genes were physically mapped using gene-specific PCR primers and the GenBridge 4 radiation hybrid panel. Nine genes, PF4, PF4V1, GRO1, GCP2, PPBP, IL8, GRO2, GRO3, and SCYB5, were assigned within a 1.8-cR interval of one another on 4q. Two additional genes, MIG and...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1998-01, Vol.47 (1), p.136-139
Main Authors: Modi, William S., Chen, Zhang-Qun
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemokines, CXC - genetics
Chromosome Mapping - methods
Chromosomes, Human, Pair 4
Classical genetics, quantitative genetics, hybrids
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Human
Humans
Hybrid Cells - radiation effects
Phylogeny
Polymerase Chain Reaction
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Summary:All 12 of the human CXC chemokine genes were physically mapped using gene-specific PCR primers and the GenBridge 4 radiation hybrid panel. Nine genes, PF4, PF4V1, GRO1, GCP2, PPBP, IL8, GRO2, GRO3, and SCYB5, were assigned within a 1.8-cR interval of one another on 4q. Two additional genes, MIG and INP10, map within 0.5 cR of each another and 6 cR distal to the above-mentioned group. The final gene, SDF1, is localized on 10q. Phylogenetic analyses of amino acid sequences revealed that SDF1 is the most divergent member and that the physically separated MIG–INP10 pair constitutes a distinct evolutionary lineage.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1997.5100