Diploid predominance in hereditary nonpolyposis colorectal carcinoma evaluated by flow cytometry

Fifty‐nine colorectal carcinomas of patients with verified cancer family syndrome (CFS) were analyzed for DNA ploidy using flow cytometry. Sixty‐eight percent of the tumors were diploid, and 32% were aneuploid. The aneuploid tumors had a median DNA index of 1.24 (range, 1.12–1.97). In 90% of all tum...

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Bibliographic Details
Published in:Cancer 1990-04, Vol.65 (8), p.1825-1829
Main Authors: Kouri, Mauri, Laasonen, Antero, Mecklin, Jukka‐Pekka, Järvinen, Heikki, Franssila, Kaarle, Pyrhönen, Seppo
Format: Article
Language:English
Subjects:
Adult
Aneuploidy
Biological and medical sciences
carcinoma
Carcinoma - genetics
Carcinoma - pathology
Cell Cycle
colon
Colonic Neoplasms - genetics
Colonic Neoplasms - pathology
Colorectal Neoplasms, Hereditary Nonpolyposis - genetics
Colorectal Neoplasms, Hereditary Nonpolyposis - pathology
Diploidy
DNA, Neoplasm - analysis
DNA, Neoplasm - genetics
Female
Flow Cytometry
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Interphase
Male
Medical sciences
Middle Aged
Prognosis
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Rate
Tumors
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Summary:Fifty‐nine colorectal carcinomas of patients with verified cancer family syndrome (CFS) were analyzed for DNA ploidy using flow cytometry. Sixty‐eight percent of the tumors were diploid, and 32% were aneuploid. The aneuploid tumors had a median DNA index of 1.24 (range, 1.12–1.97). In 90% of all tumors the DNA index was less than 1.27. This predominance of diploid/near‐diploid tumors was seen both in primary and in metachronous carcinomas. In 21 cases a cell cycle analysis was possible. Tumors with the S‐phase fraction (SPF) ± 9.8% had a worse prognosis than tumors with the SPF of
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19900415)65:8<1825::AID-CNCR2820650827>3.0.CO;2-H