Respiratory Syncytial Virus Affects Pulmonary Function in BALB/c Mice

BALB/c mice inoculated intranasally with respiratory syncytial virus (RSV) were studied in a whole-body plethysmograph to determine if signs of respiratory illness similar to those observed in human infants could be detected. Also, responsiveness to methacholine was assessed. RSV-infected mice showe...

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Bibliographic Details
Published in:The Journal of infectious diseases 1998-02, Vol.177 (2), p.269-276
Main Authors: Schaik, Sandrijn M. van, Enhorning, Goran, Vargas, Ida, Welliver, Robert C.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Bronchial Hyperreactivity - diagnosis
Bronchial Hyperreactivity - physiopathology
Bronchial Provocation Tests
Bronchoalveolar Lavage Fluid - cytology
Cells, Cultured
Disease Models, Animal
Dosage
Experimental viral diseases and models
Human respiratory syncytial virus
Infections
Infectious diseases
Inoculation
Leukocyte Count
Lungs
Lymphocyte Count
Lymphocytes
Lymphocytes - immunology
Major Articles
Medical sciences
Methacholine Chloride - pharmacology
Mice
Mice, Inbred BALB C
Neutrophils - immunology
Plethysmography, Whole Body
Respiratory rate
Respiratory syncytial virus infections
Respiratory Syncytial Virus Infections - diagnosis
Respiratory Syncytial Virus Infections - physiopathology
Respiratory Syncytial Virus Infections - virology
Respiratory Syncytial Virus, Human - growth & development
Respiratory Syncytial Virus, Human - pathogenicity
Respiratory syncytial viruses
Viral diseases
Weight Loss
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Description
Summary:BALB/c mice inoculated intranasally with respiratory syncytial virus (RSV) were studied in a whole-body plethysmograph to determine if signs of respiratory illness similar to those observed in human infants could be detected. Also, responsiveness to methacholine was assessed. RSV-infected mice showed significantly higher respiratory rates than did controls (409.2 vs. 305.2 breaths/min, P < .0001). Significantly increased airway responsiveness to methacholine was noted, infected mice responding to a 100-fold lower dose than controls (P = .003). Together, these data provide the first objective evidence of respiratory illness in the mouse model of RSV infection, which enhances the value of this model for evaluating effects of vaccines, antivirals, and other drugs acting on respiratory tract disease caused by RSV.
ISSN:0022-1899
1537-6613
DOI:10.1086/514208