Mapping of the Human Genes Encoding Cyclin H (CCNH) and the CDK-Activating Kinase (CAK) Assembly Factor MAT1 (MNAT1) to Chromosome Bands 5q13.3–q14 and 14q23, Respectively

Cyclin-dependent kinases (CDKs), which play a key role in cell cycle control, are activated by the CDK-activating kinase (CAK), which activates cyclin-bound CDKs by phosphorylation at the specific threonine residue. Mammalian CAK contains three components: CDK7, cyclin H, and an assembly factor call...

Full description

Saved in:
Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1998-01, Vol.47 (1), p.115-120
Main Authors: Eki, Toshihiko, Okumura, Katsuzumi, Abe, Makoto, Kagotani, Kazuhiro, Taguchi, Hiroshi, Murakami, Yasufumi, Pan, Zhen-Qiang, Hanaoka, Fumio
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Biological and medical sciences
Blotting, Southern
Carrier Proteins
Chromosome Mapping
Chromosomes, Artificial, Yeast
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 5
Classical genetics, quantitative genetics, hybrids
Cricetinae
Cyclin H
Cyclin-Dependent Kinases
Cyclins - genetics
Fundamental and applied biological sciences. Psychology
Genetic Markers
Genetics of eukaryotes. Biological and molecular evolution
Human
Humans
Hybrid Cells
In Situ Hybridization, Fluorescence
Mice
Molecular Sequence Data
Polymerase Chain Reaction
Protein-Serine-Threonine Kinases - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cyclin-dependent kinases (CDKs), which play a key role in cell cycle control, are activated by the CDK-activating kinase (CAK), which activates cyclin-bound CDKs by phosphorylation at the specific threonine residue. Mammalian CAK contains three components: CDK7, cyclin H, and an assembly factor called MAT1. The CDK7–cyclin H–MAT1 complex is tightly associated with a multiprotein complex TFIIH, which plays a dual role in transcription and DNA repair. Here, we have determined chromosomal localizations of the human genes encoding cyclin H (CCNH) and MAT1 (HGMW-approved symbol MNAT1) to chromosome bands 5q13.3–q14 and 14q23, respectively, by using fluorescencein situhybridization, somatic cell hybrid analyses, and mapping to the human YAC contigs.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1997.5053