Glucose Metabolic Rate in Normals and Schizophrenics During the Continuous Performance Test Assessed by Positron Emission Tomography

Local cerebral uptake of glucose labelled with fluorine-18 was measured by positron emission tomography in 13 patients with schizophrenia and 37 right-handed volunteers. Patients received no medication for a minimum of 31 days and a mean of 30 weeks. The subjects were administered the labelled deoxy...

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Bibliographic Details
Published in:British journal of psychiatry 1990-02, Vol.156 (2), p.216-227
Main Authors: Buchsbaum, Monte S., Nuechterlein, Keith H., Haier, Richard J., Wu, Joseph, Sicotte, Nancy, Hazlett, Erin, Asarnow, Robert, Potkin, Stephen, Guich, Steven
Format: Article
Language:English
Subjects:
Adult
Antipsychotics
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - metabolism
Continuous performance tasks
Cortex
Cortex (frontal)
Deoxyglucose
Deoxyglucose - analogs & derivatives
Emissions
Female
Fluorodeoxyglucose F18
Frontal Lobe - metabolism
Glucose
Glucose - metabolism
Handedness
Humans
Male
Mental disorders
Metabolic rate
Metabolism
Positron emission tomography
Psychological Tests
Schizophrenia
Schizophrenia - metabolism
Task performance
Tomography
Tomography, Emission-Computed
Uptake
Visual cortex
Visual Perception
Visual stimuli
Volunteers
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Summary:Local cerebral uptake of glucose labelled with fluorine-18 was measured by positron emission tomography in 13 patients with schizophrenia and 37 right-handed volunteers. Patients received no medication for a minimum of 31 days and a mean of 30 weeks. The subjects were administered the labelled deoxyglucose just after the beginning of a 32-minute sequence of blurred numbers as visual stimuli for the Continuous Performance Test. In normal controls, task performance was associated with increases in glucose metabolic rate in the right frontal and right temporoparietal regions; occipital rates were unchanged. Patients with schizophrenia showed both absolutely and relatively reduced metabolic rates in the frontal cortex and in the temporoparietal regions compared with normal controls.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.156.2.216