Permeability of the normal rat brain, spinal cord and dorsal root ganglia microcirculations to immunoglobulins G

The distribution of blood-borne immunoglobulins G (IgG) was studied in the cerebral cortex, pineal gland, spinal cord and dorsal root ganglia of normal Lewis rats using the detection of autologous anti-horseradish peroxidase (HRP) antibodies. This detection was performed by means of light and electr...

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Bibliographic Details
Published in:Biology of the cell 1990, Vol.68 (1), p.31-36
Main Authors: Azzi, Georges, Bernaudin, Jean-François, Bouchaud, Claude, Bellon, Blanche, Fleury-Feith, Jocelyne
Format: Article
Language:English
Subjects:
Animals
anti-HRP IgG-brain spinal cord
blood-brain barrier
Blood-Brain Barrier - physiology
Brain - blood supply
Brain - metabolism
Capillary Permeability - physiology
Cerebral Cortex - metabolism
electron microscopy
Ganglia, Spinal - blood supply
Ganglia, Spinal - metabolism
Horseradish Peroxidase - immunology
Immunoglobulin G - metabolism
Pineal Gland - metabolism
rat
Rats
Rats, Inbred Lew
Spinal Cord - blood supply
Spinal Cord - metabolism
spinal ganglion
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Summary:The distribution of blood-borne immunoglobulins G (IgG) was studied in the cerebral cortex, pineal gland, spinal cord and dorsal root ganglia of normal Lewis rats using the detection of autologous anti-horseradish peroxidase (HRP) antibodies. This detection was performed by means of light and electron microscopy. This study demonstrated that, in the cerebral cortex and the spinal cord microcirculations, endothelial cells are a restrictive barrier against IgG while IgG are able to diffuse into the perivascular parenchyma of the pineal gland and spinal ganglia.
ISSN:0248-4900
1768-322X
DOI:10.1016/0248-4900(90)90283-9