Human CD28 and CTLA-4 Ig superfamily genes are located on chromosome 2 at bands q33-q34

CD28 is a cell surface molecule present on most peripheral T cells which has been implied in the amplification of the T-cell response in vitro. Using in situ hybridization on human prometaphase cells, we have found that the human CD28 gene maps to chromosome 2 at bands q33-q34, as shown previously f...

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Bibliographic Details
Published in:Immunogenetics (New York) 1990-03, Vol.31 (3), p.198-201
Main Authors: LAFAGE-POCHITALOFF, M, COSTELLO, R, COUEZ, D, SIMONETTI, J, MANNONI, P, MAWAS, C, OLIVE, D
Format: Article
Language:English
Subjects:
Antigens, CD - genetics
Antigens, Differentiation, T-Lymphocyte - genetics
Autoradiography
Biological and medical sciences
CD28 Antigens
Chromosome Mapping
Chromosomes, Human, Pair 2 - analysis
Classical genetics, quantitative genetics, hybrids
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Human
Humans
Male
Multigene Family
Nucleic Acid Hybridization
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Summary:CD28 is a cell surface molecule present on most peripheral T cells which has been implied in the amplification of the T-cell response in vitro. Using in situ hybridization on human prometaphase cells, we have found that the human CD28 gene maps to chromosome 2 at bands q33-q34, as shown previously for the CTLA-4 gene. CD28 and CTLA-4 are both members of the Ig superfamily, where they define a subgroup of membrane-bound single V domains. Their chromosomal proximity and their close structural relationship suggest that these two genes could be the result of the duplication of a common evolutionary precursor and may share some functional properties.
ISSN:0093-7711
1432-1211
DOI:10.1007/bf00211556