Rising Incidence of Breast Cancer: Relationship to Stage and Receptor Status

we used the population-based tumor registry of Kaiser Permanente in the United States (Portland, OR) to analyze breast cancer incidence from 1960 to 1985. Overall, incidence rose 45% during this period. The largest increases occurred in women 60 years of age or older (74%) and in those 45–59 (36%)....

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1990-04, Vol.82 (8), p.693-696
Main Authors: Glass, Andrew G., Hoover, Robert N.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Breast Neoplasms - analysis
Breast Neoplasms - epidemiology
Breast Neoplasms - mortality
Female
Gynecology. Andrology. Obstetrics
Humans
Incidence
Medical sciences
Middle Aged
Neoplasm Staging
Receptors, Estrogen - analysis
Registries
Survival Rate
Time Factors
United States - epidemiology
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Summary:we used the population-based tumor registry of Kaiser Permanente in the United States (Portland, OR) to analyze breast cancer incidence from 1960 to 1985. Overall, incidence rose 45% during this period. The largest increases occurred in women 60 years of age or older (74%) and in those 45–59 (36%). The rate in women aged 20–44 has remained essentially unchanged. Localized and regional disease showed similar increases. Review of medical records revealed that only a small portion of this increase was likely to result from increased screening activities. From the increased availability of receptor assays in a large proportion of cases since the mid-1970s, we observed that incidence of estrogen receptor-negative cancers rose 22%–27% between the mid-1970s and the mid-1980s. In contrast, incidence of estrogen receptor-positive tumors increased an average of 131% in the same period, perhaps implicating hormonal factors in the rising incidence of breast cancer. [J Natl Cancer Inst 82:693–696,1990]
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/82.8.693