Characterization of a High Capacity Calcium Transport System in Mitochondria of the Yeast Endomyces magnusii

The Ca 2+ transport system of Endomyces magnusii mitochondria has been shown previously to be activated by spermine. Here we report it to be regulated also by low, physiological ADP concentrations, by the intramitochondrial NADH/NAD + ratio, and by Ca 2+ ions. The combination of all these physiologi...

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Bibliographic Details
Published in:The Journal of biological chemistry 1998-02, Vol.273 (8), p.4372-4377
Main Authors: Bazhenova, E N, Deryabina, Y I, Eriksson, O, Zvyagilskaya, R A, Saris, N E
Format: Article
Language:English
Subjects:
Adenosine Diphosphate - metabolism
Atractyloside - pharmacology
Calcium - metabolism
Ion Transport
Mitochondria - drug effects
Mitochondria - metabolism
NAD - metabolism
Saccharomycetales - metabolism
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Summary:The Ca 2+ transport system of Endomyces magnusii mitochondria has been shown previously to be activated by spermine. Here we report it to be regulated also by low, physiological ADP concentrations, by the intramitochondrial NADH/NAD + ratio, and by Ca 2+ ions. The combination of all these physiological modulators induced high initial rates of Ca 2+ uptake and high Ca 2+ -buffering capacity of yeast mitochondria, enabling them to lower the medium [Ca 2+ ] to ∼0.2 μ m . The mechanisms of stimulation by these agents are discussed.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.273.8.4372