Separation of enantiomers of drugs by capillary electrophoresis: V. Hydroxypropyl-α-cyclodextrin as chiral solvating agent

In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-α-cyclodextrin as chiral solvating agent (CSA). A total of 34 drugs out of 86 could be resolved in this straightforward approach. The number of experiments performed under identical cond...

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Bibliographic Details
Published in:Journal of Chromatography A 1998-01, Vol.793 (1), p.153-164
Main Authors: Koppenhoefer, Bernhard, Epperlein, Ulrich, Schlunk, Rainer, Zhu, Xiaofeng, Lin, Bingcheng
Format: Article
Language:English
Subjects:
2-Hydroxypropyl-beta-cyclodextrin
alpha-Cyclodextrins
Analysis
Analytical chemistry
beta-Cyclodextrins
Biological and medical sciences
Chemistry
Chromatographic methods and physical methods associated with chromatography
Cyclodextrins
Cyclodextrins - chemistry
Drugs, chiral
Electrophoresis, Capillary - methods
Exact sciences and technology
General pharmacology
Medical sciences
Other chromatographic methods
Pharmaceutical Preparations - analysis
Pharmaceutical Preparations - chemistry
Pharmacology. Drug treatments
Stereoisomerism
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Summary:In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-α-cyclodextrin as chiral solvating agent (CSA). A total of 34 drugs out of 86 could be resolved in this straightforward approach. The number of experiments performed under identical conditions allows a correlation of the separation factors α m with the interaction strengths R m. As shown for a subset of 23 drugs, the concentration of the CSA is a crucial parameter for further optimization.
ISSN:0021-9673
DOI:10.1016/S0021-9673(97)00880-7