Ischemia induces a reduction in the content of ulinastatin-like substance in the murine hippocampus

Effects of ischemia on the content of a ulinastatin (UT)-like substance in the murine cerebral cortex and hippocampus were studied. At 24 h post-ischemia, a significant (p < 0.05) decrease in the content of UT-like substance in the hippocampus but not the cerebral cortex and a concurrent increase...

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Bibliographic Details
Published in:Neurochemical research 1998, Vol.23 (1), p.69-72
Main Authors: SHIKIMI, T, GONDA, T, TAKAHASHI, M, KANETO, H, OKUNISHI, H, TAKAORI, S
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Calcium Chloride - pharmacology
Calcium-Binding Proteins - pharmacology
Calpain - metabolism
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Edetic Acid - pharmacology
Glycoproteins - metabolism
Hippocampus - drug effects
Hippocampus - metabolism
Ischemia
Ischemic Attack, Transient - metabolism
Kinetics
Male
Medical sciences
Mice
Mice, Inbred ICR
Neurology
Trypsin Inhibitors - metabolism
Vascular diseases and vascular malformations of the nervous system
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Summary:Effects of ischemia on the content of a ulinastatin (UT)-like substance in the murine cerebral cortex and hippocampus were studied. At 24 h post-ischemia, a significant (p < 0.05) decrease in the content of UT-like substance in the hippocampus but not the cerebral cortex and a concurrent increase in the activity of micro-calpain were observed. In in vitro experiments, a decrease was registered in the content of UT-like substance in the hippocampus in the presence of calcium. This decrease was inhibited by both EDTA and calpastatin treatments. These results implicate the destruction of UT-like substance by micro-calpain in the ischemic hippocampus.
ISSN:0364-3190
1573-6903
DOI:10.1023/A:1022453504527