Self-reactive B cells in nonautoimmune and autoimmune mice

The defining feature of autoimmune disease is the presence of specific autoreactive lymphocytes. Systemic lupus erythematosus (SLE), for example, is characterized by a discrete set of antibodies directed to nuclear antigens; these include autoantibodies to DNA and snRNPs that are diagnostic for SLE....

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Bibliographic Details
Published in:Immunologic research 1998, Vol.17 (1-2), p.49-61
Main Authors: Erikson, J, Mandik, L, Bui, A, Eaton, A, Noorchashm, H, Nguyen, K A, Roark, J H
Format: Article
Language:English
Subjects:
Animals
Antibodies, Antinuclear - immunology
Autoantigens - immunology
Autoimmune diseases
Autoimmunity
B-Lymphocytes - immunology
Cellular biology
Immune system
Immunology
Lupus
Lupus Erythematosus, Systemic - immunology
Mice
Mice, Inbred BALB C
Mice, Mutant Strains
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Summary:The defining feature of autoimmune disease is the presence of specific autoreactive lymphocytes. Systemic lupus erythematosus (SLE), for example, is characterized by a discrete set of antibodies directed to nuclear antigens; these include autoantibodies to DNA and snRNPs that are diagnostic for SLE. The murine model of SLE, the MRL-lpr/lpr mouse, likewise, has a similar autoantibody profile. To understand how SLE-associated autoantibodies are regulated in healthy individuals and to identify mechanisms underlying their expression in autoimmunity, we have developed a transgenic (tg) model system using multiple sets of tgs. The development of B cells bearing these tgs has been studied in BALB/c and MRL-lpr/lpr autoimmune backgrounds, and the relative fates of anti-ssDNA and anti-dsDNA tg B cells when they are a part of a diverse as well as monoclonal B cell repertoire have been evaluated.
ISSN:0257-277X
1559-0755
DOI:10.1007/bf02786430