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Effect of filtration and storage of platelet concentrates on the production of the chemotaxins C5a, interleukin 8, tumor necrosis factor alpha, and leukotriene B4
BACKGROUND: The production in platelet concentrates (PCs) of C3 activation products (C3bc), terminal complement complex (TCC), and chemotaxins C5a, interleukin (IL)‐8, tumor necrosis factor alpha (TNFalpha), and leukotriene B4 (LTB4) and the proposed reduction in concentration of the chemotaxins by...
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Published in: | Transfusion (Philadelphia, Pa.) Pa.), 1998-01, Vol.38 (1), p.16-23 |
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creator | Hetland, G Mollnes, T.E Bergh, K Hogasen, K Bergerud, U.E Solheim, B.G |
description | BACKGROUND: The production in platelet concentrates (PCs) of C3 activation products (C3bc), terminal complement complex (TCC), and chemotaxins C5a, interleukin (IL)‐8, tumor necrosis factor alpha (TNFalpha), and leukotriene B4 (LTB4) and the proposed reduction in concentration of the chemotaxins by white cell reduction were examined. STUDY DESIGN AND METHODS: Samples were collected from supernatants of PCs produced by apheresis (apheresis PCs) or from buffy coats (BC PCs) immediately after the production, after white cell‐reduction filtration on Day 1, and after 5‐day storage, and examined by enzyme immunoassays. RESULTS: Complement was activated in all PCs during storage, and the concentration of activation products was not influenced by prestorage filtration. In prestorage white cell‐reduced BC PCs, only C3bc levels increased. Levels of IL‐8, TNFalpha, and LTB4 increased during storage of apheresis PCs, but not in filtered units, except for LTB4. In contrast, levels of IL‐8 decreased after storage of filtered BC PCs. C5a correlated significantly with IL‐8, which also correlated with TNFalpha and LTB4. CONCLUSION: Both C5a and TNFalpha generation in apheresis PCs seem to induce white cell IL‐8 production, which mediates cellular LTB4 release. Prestorage white cell reduction is recommended for reducing chemotactic cytokine and leukotriene levels in all PCs. Production of BC PCs is recommended to achieve less complement activation, which is not affected by filtration. |
doi_str_mv | 10.1046/j.1537-2995.1998.38198141493.x |
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STUDY DESIGN AND METHODS: Samples were collected from supernatants of PCs produced by apheresis (apheresis PCs) or from buffy coats (BC PCs) immediately after the production, after white cell‐reduction filtration on Day 1, and after 5‐day storage, and examined by enzyme immunoassays. RESULTS: Complement was activated in all PCs during storage, and the concentration of activation products was not influenced by prestorage filtration. In prestorage white cell‐reduced BC PCs, only C3bc levels increased. Levels of IL‐8, TNFalpha, and LTB4 increased during storage of apheresis PCs, but not in filtered units, except for LTB4. In contrast, levels of IL‐8 decreased after storage of filtered BC PCs. C5a correlated significantly with IL‐8, which also correlated with TNFalpha and LTB4. CONCLUSION: Both C5a and TNFalpha generation in apheresis PCs seem to induce white cell IL‐8 production, which mediates cellular LTB4 release. Prestorage white cell reduction is recommended for reducing chemotactic cytokine and leukotriene levels in all PCs. Production of BC PCs is recommended to achieve less complement activation, which is not affected by filtration.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1046/j.1537-2995.1998.38198141493.x</identifier><identifier>PMID: 9482389</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>Edinburgh, UK: Blackwell Science Ltd</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Platelets - chemistry ; Blood Preservation - adverse effects ; Blood Preservation - methods ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Complement Activation ; Complement C5a - analysis ; Filtration ; Humans ; Interleukin-8 - blood ; Leukotriene B4 - blood ; Medical sciences ; Platelet Activation ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Tumor Necrosis Factor-alpha - analysis</subject><ispartof>Transfusion (Philadelphia, Pa.), 1998-01, Vol.38 (1), p.16-23</ispartof><rights>1998 AABB</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2160117$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9482389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hetland, G</creatorcontrib><creatorcontrib>Mollnes, T.E</creatorcontrib><creatorcontrib>Bergh, K</creatorcontrib><creatorcontrib>Hogasen, K</creatorcontrib><creatorcontrib>Bergerud, U.E</creatorcontrib><creatorcontrib>Solheim, B.G</creatorcontrib><title>Effect of filtration and storage of platelet concentrates on the production of the chemotaxins C5a, interleukin 8, tumor necrosis factor alpha, and leukotriene B4</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND: The production in platelet concentrates (PCs) of C3 activation products (C3bc), terminal complement complex (TCC), and chemotaxins C5a, interleukin (IL)‐8, tumor necrosis factor alpha (TNFalpha), and leukotriene B4 (LTB4) and the proposed reduction in concentration of the chemotaxins by white cell reduction were examined. STUDY DESIGN AND METHODS: Samples were collected from supernatants of PCs produced by apheresis (apheresis PCs) or from buffy coats (BC PCs) immediately after the production, after white cell‐reduction filtration on Day 1, and after 5‐day storage, and examined by enzyme immunoassays. RESULTS: Complement was activated in all PCs during storage, and the concentration of activation products was not influenced by prestorage filtration. In prestorage white cell‐reduced BC PCs, only C3bc levels increased. Levels of IL‐8, TNFalpha, and LTB4 increased during storage of apheresis PCs, but not in filtered units, except for LTB4. In contrast, levels of IL‐8 decreased after storage of filtered BC PCs. C5a correlated significantly with IL‐8, which also correlated with TNFalpha and LTB4. CONCLUSION: Both C5a and TNFalpha generation in apheresis PCs seem to induce white cell IL‐8 production, which mediates cellular LTB4 release. Prestorage white cell reduction is recommended for reducing chemotactic cytokine and leukotriene levels in all PCs. Production of BC PCs is recommended to achieve less complement activation, which is not affected by filtration.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - chemistry</subject><subject>Blood Preservation - adverse effects</subject><subject>Blood Preservation - methods</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Complement Activation</subject><subject>Complement C5a - analysis</subject><subject>Filtration</subject><subject>Humans</subject><subject>Interleukin-8 - blood</subject><subject>Leukotriene B4 - blood</subject><subject>Medical sciences</subject><subject>Platelet Activation</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNpNkdFu0zAUhiMEGmXwCEi-QLtaio8dJ_YlVGuHNoFAQ1xannNM3aVOZzuiex2elGStKq4snf_zf2R_RXEBdA60qj9u5iB4UzKlxByUknMuQUmooFJ8vn9RzE7xy2JGaQUlAGevizcpbSilTFE4K85UJRmXalb8vXIObSa9I853OZrs-0BMaEnKfTS_cUp2ncnYYSa2DxbDRGEiI5fXSHaxbwf7fG1Ep4ld47bPZu9DIgthLokPGWOHw4MPRF6SPGz7SALa2CefiDN2XEVMt1uP7LR6QvscPQYkn6u3xStnuoTvjud58XN5dbe4Lm-_rb4sPt2WnlWSl0JI0VpBjQLVNHVtBNi2ugewlhtBXesUSqaYtC1DAAqukgCOydrgOJL8vLg49I4vehwwZb31yWLXmYD9kHSjGsqEhBF8fwSH-y22ehf91sQnffzUMf9wzE2ypnPRBOvTCWNQU4BmxBYH7I_v8OkUA9WTaL3Rk0k9mdSTaP2faL3Xdz-WTFI-tpSHFp8y7k8tJj7ouuGN0L--rvT35Q1vrle1rvg_a6ytdg</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>Hetland, G</creator><creator>Mollnes, T.E</creator><creator>Bergh, K</creator><creator>Hogasen, K</creator><creator>Bergerud, U.E</creator><creator>Solheim, B.G</creator><general>Blackwell Science Ltd</general><general>Blackwell Publishing</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199801</creationdate><title>Effect of filtration and storage of platelet concentrates on the production of the chemotaxins C5a, interleukin 8, tumor necrosis factor alpha, and leukotriene B4</title><author>Hetland, G ; Mollnes, T.E ; Bergh, K ; Hogasen, K ; Bergerud, U.E ; Solheim, B.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2483-5585dc50a9197766a51cd4b11cc3a50fdf9e82928cd2e1101f4811f286aecd283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - chemistry</topic><topic>Blood Preservation - adverse effects</topic><topic>Blood Preservation - methods</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Complement Activation</topic><topic>Complement C5a - analysis</topic><topic>Filtration</topic><topic>Humans</topic><topic>Interleukin-8 - blood</topic><topic>Leukotriene B4 - blood</topic><topic>Medical sciences</topic><topic>Platelet Activation</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hetland, G</creatorcontrib><creatorcontrib>Mollnes, T.E</creatorcontrib><creatorcontrib>Bergh, K</creatorcontrib><creatorcontrib>Hogasen, K</creatorcontrib><creatorcontrib>Bergerud, U.E</creatorcontrib><creatorcontrib>Solheim, B.G</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hetland, G</au><au>Mollnes, T.E</au><au>Bergh, K</au><au>Hogasen, K</au><au>Bergerud, U.E</au><au>Solheim, B.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of filtration and storage of platelet concentrates on the production of the chemotaxins C5a, interleukin 8, tumor necrosis factor alpha, and leukotriene B4</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>1998-01</date><risdate>1998</risdate><volume>38</volume><issue>1</issue><spage>16</spage><epage>23</epage><pages>16-23</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND: The production in platelet concentrates (PCs) of C3 activation products (C3bc), terminal complement complex (TCC), and chemotaxins C5a, interleukin (IL)‐8, tumor necrosis factor alpha (TNFalpha), and leukotriene B4 (LTB4) and the proposed reduction in concentration of the chemotaxins by white cell reduction were examined. STUDY DESIGN AND METHODS: Samples were collected from supernatants of PCs produced by apheresis (apheresis PCs) or from buffy coats (BC PCs) immediately after the production, after white cell‐reduction filtration on Day 1, and after 5‐day storage, and examined by enzyme immunoassays. RESULTS: Complement was activated in all PCs during storage, and the concentration of activation products was not influenced by prestorage filtration. In prestorage white cell‐reduced BC PCs, only C3bc levels increased. Levels of IL‐8, TNFalpha, and LTB4 increased during storage of apheresis PCs, but not in filtered units, except for LTB4. In contrast, levels of IL‐8 decreased after storage of filtered BC PCs. C5a correlated significantly with IL‐8, which also correlated with TNFalpha and LTB4. CONCLUSION: Both C5a and TNFalpha generation in apheresis PCs seem to induce white cell IL‐8 production, which mediates cellular LTB4 release. Prestorage white cell reduction is recommended for reducing chemotactic cytokine and leukotriene levels in all PCs. Production of BC PCs is recommended to achieve less complement activation, which is not affected by filtration.</abstract><cop>Edinburgh, UK</cop><pub>Blackwell Science Ltd</pub><pmid>9482389</pmid><doi>10.1046/j.1537-2995.1998.38198141493.x</doi><tpages>8</tpages></addata></record> |
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subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Platelets - chemistry Blood Preservation - adverse effects Blood Preservation - methods Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Complement Activation Complement C5a - analysis Filtration Humans Interleukin-8 - blood Leukotriene B4 - blood Medical sciences Platelet Activation Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tumor Necrosis Factor-alpha - analysis |
title | Effect of filtration and storage of platelet concentrates on the production of the chemotaxins C5a, interleukin 8, tumor necrosis factor alpha, and leukotriene B4 |
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