An expression of anaplastic large cell lymphoma-associated antigens on HTLV-I-infected CD4+ T cells

We investigated tumor-associated antigens induced by infection with human T-lymphotropic virus type I(HTLV-I). Anaplastic large cell lymphoma (APLL) antigens were found to be expressed on interleukin 2 (IL-2)-dependent, HTLV-I-infected CD4+ T-cell lines established from patients with adult T-cell le...

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Bibliographic Details
Published in:Annals of hematology 1998-01, Vol.76 (1), p.31-35
Main Authors: MAKINO, M, YASHIKI, S, FUJIYOSHI, T, BABA, M, SONODA, S
Format: Article
Language:English
Subjects:
AIDS/HIV
Biological and medical sciences
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - metabolism
Cell Line, Transformed
Cells, Cultured
Hematologic and hematopoietic diseases
HTLV-I Infections - metabolism
Humans
Interleukin-2 - pharmacology
Interleukin-4 - pharmacology
Ki-1 Antigen - metabolism
Leukemia, T-Cell - complications
Leukemia, T-Cell - metabolism
Leukemia-Lymphoma, Adult T-Cell - metabolism
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - metabolism
Leukocytes, Mononuclear - virology
Medical sciences
Paraparesis, Tropical Spastic - complications
Paraparesis, Tropical Spastic - metabolism
Phytohemagglutinins - pharmacology
Time Factors
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Summary:We investigated tumor-associated antigens induced by infection with human T-lymphotropic virus type I(HTLV-I). Anaplastic large cell lymphoma (APLL) antigens were found to be expressed on interleukin 2 (IL-2)-dependent, HTLV-I-infected CD4+ T-cell lines established from patients with adult T-cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis. However, APLL antigens were not detected on unstimulated lymphocytes, mitogen-activated T lymphocytes, or Epstein-Barr virus-infected B cells. Furthermore, APLL antigens were not found on IL-2-independent HTLV-I-transformed cells such as MT-I or MT-2. When naive CD4+ T cells were infected with HTLV-I in vitro in the presence of IL-2, the APLL antigens were detected on them 4 weeks after infection. The expression level increased in a time-dependent fashion. These results indicate that HTLV-I infection induces a unique category of tumor-associated antigens on CD4+ T cells.
ISSN:0939-5555
1432-0584
DOI:10.1007/s002770050357