Unsuspected uterine leiomyosarcoma discovered during treatment with a gonadotropin-releasing hormone analogue: A case report and literature review

We report a case of a 37-year-old woman who had received five courses of gonadotropin-releasing hormone (GnRH) agonist (Decapeptyl) for presumed uterine leiomyomata associated with episodes of uterine bleeding. Submucous myoma (histologically proven) was partially removed on the first visit. After a...

Full description

Saved in:
Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 1998-02, Vol.76 (2), p.237-240
Main Authors: Milman, D, Zalel, Y, Biran, H, Open, M, Caspi, B, Hagay, Z, Dgani, R
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Agents, Hormonal - therapeutic use
Biological and medical sciences
Diagnosis, Differential
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Hysterectomy
Leiomyoma
Leiomyosarcoma - diagnosis
Leiomyosarcoma - pathology
Leiomyosarcoma - surgery
Medical sciences
Mitosis
Triptorelin Pamoate - therapeutic use
Tumors
Uterine Hemorrhage
Uterine Neoplasms - diagnosis
Uterine Neoplasms - drug therapy
Uterine Neoplasms - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report a case of a 37-year-old woman who had received five courses of gonadotropin-releasing hormone (GnRH) agonist (Decapeptyl) for presumed uterine leiomyomata associated with episodes of uterine bleeding. Submucous myoma (histologically proven) was partially removed on the first visit. After a period of significant reduction in the tumor size and cessation of uterine bleeding, the symptoms recurred along with rapid re-growth of the uterus. Total abdominal hysterectomy was performed and the pathologic evaluation revealed leiomyosarcoma with a high mitotic rate. This case and the literature review emphasize the problems encountered with the early diagnosis of uterine leiomyosarcoma during GnRH agonist therapy.
ISSN:0301-2115
1872-7654
DOI:10.1016/S0301-2115(97)00211-X