Delayed gastric emptying by Helicobacter pylori lipopolysaccharide in conscious rats

The present study was carried out to investigate the possibility that lipopolysaccharide deprived from Helicobacter pylori may alter gastric motility. To address the question, we examined the effect of H. pylori lipopolysaccharide on gastric emptying in conscious rats. Gastric emptying was evaluated...

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Bibliographic Details
Published in:Digestive diseases and sciences 1998, Vol.43 (1), p.90-94
Main Authors: OKUMURA, T, SHOJI, E, TAKAHASHI, N, WAKEBE, H, IMAGAWA, K, KIKUCHI, M, KOHGO, Y
Format: Article
Language:English
Subjects:
Animals
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Dose-Response Relationship, Drug
Gastric Emptying - drug effects
Gastric Emptying - physiology
Helicobacter Infections - physiopathology
Helicobacter pylori
Human bacterial diseases
Infectious diseases
Injections, Intraperitoneal
Lipopolysaccharides - administration & dosage
Lipopolysaccharides - pharmacology
Male
Medical sciences
Rats
Rats, Sprague-Dawley
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Summary:The present study was carried out to investigate the possibility that lipopolysaccharide deprived from Helicobacter pylori may alter gastric motility. To address the question, we examined the effect of H. pylori lipopolysaccharide on gastric emptying in conscious rats. Gastric emptying was evaluated by the phenol red method. Time-course and dose-related effects of intraperitoneal administration of H. pylori lipopolysaccharide were investigated. Intraperitoneal injection of H. pylori lipopolysaccharide significantly suppressed gastric emptying of a liquid meal in a dose-dependent manner. The inhibitory action of H. pylori lipopolysaccharide was observed 2, 4, 8, or 12 hr after the injection. These results suggest for the first time that H. pylori lipopolysaccharide may suppress gastric emptying in a long-lasting fashion. It is also suggested that H. pylori may influence gastric function through its cell wall structure named lipopolysaccharide.
ISSN:0163-2116
1573-2568
DOI:10.1023/a:1018828105226