Recurrent chromosome changes in two adult fibrosarcomas

Cytogenetic analysis of two adult fibrosarcomas revealed clonal chromosomal rearrangements including unbalanced translocations between chromosomes 2 and 19, with the same segment, 2q21‐qter, translocated onto 19p13 in one tumor and 19q13 in another; and partial monosomy of 10q due to add(10)(q22) an...

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Bibliographic Details
Published in:Genes chromosomes & cancer 1998-02, Vol.21 (2), p.119-123
Main Authors: Limon, Janusz, Szadowska, Anna, Iliszko, Mariola, Babińska, Małgorzata, Mrózek, Krzysztof, Jaśkiewicz, Janusz, Kopacz, Andrzej, Roszkiewicz, Andrzej, Dębiec-Rychter, Maria
Format: Article
Language:English
Subjects:
Adolescent
Adult
Chromosome Aberrations - genetics
Chromosome Aberrations - pathology
Chromosome Disorders
Chromosomes, Human, Pair 10 - genetics
Chromosomes, Human, Pair 19 - genetics
Chromosomes, Human, Pair 2 - genetics
Fatal Outcome
Female
Fibrosarcoma - genetics
Fibrosarcoma - pathology
Humans
Karyotyping
Male
Muscle Neoplasms - genetics
Muscle Neoplasms - pathology
Neoplasm Recurrence, Local - genetics
Neoplasm Recurrence, Local - pathology
Translocation, Genetic - genetics
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Summary:Cytogenetic analysis of two adult fibrosarcomas revealed clonal chromosomal rearrangements including unbalanced translocations between chromosomes 2 and 19, with the same segment, 2q21‐qter, translocated onto 19p13 in one tumor and 19q13 in another; and partial monosomy of 10q due to add(10)(q22) and del(10)(q22q25) seen in one tumor each. This is the first description of nonrandom chromosomal changes in adult fibrosarcoma. Genes Chromosomes Cancer 21:119–123, 1998. © 1998 Wiley‐Liss, Inc.
ISSN:1045-2257
1098-2264
DOI:10.1002/(SICI)1098-2264(199802)21:2<119::AID-GCC7>3.0.CO;2-3