Trophoblast glycoprotein recognised by monoclonal antibody 5T4 maps to human chromosome 6Q14-Q15

Human X rodent hybrids were stained by indirect immunofluorescence with 5T4, a murine monoclonal antibody that recognises a 72 kdalton glycoprotein expressed by human trophoblasts and a very restricted range of adult tissues; they were analysed by flow cytometry. Concordance analysis supported by se...

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Bibliographic Details
Published in:Human genetics 1990-04, Vol.84 (5), p.455-458
Main Authors: BOYLE, J. M, GRZESCHILK, K.-H, HEATH, P. R, MORTEN, J. E, STERN, P. L
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal
Biological and medical sciences
Biomarkers - analysis
chromosome 6
Chromosome Banding
Chromosomes, Human, Pair 6
Classical genetics, quantitative genetics, hybrids
Cricetinae
Cricetulus
Female
Fundamental and applied biological sciences. Psychology
genes
Genetic Markers
Genetics of eukaryotes. Biological and molecular evolution
Human
Humans
Hybrid Cells
Membrane Glycoproteins - genetics
Membrane Glycoproteins - immunology
Pregnancy
Pregnancy Proteins - genetics
Pregnancy Proteins - immunology
Trophoblasts - immunology
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Summary:Human X rodent hybrids were stained by indirect immunofluorescence with 5T4, a murine monoclonal antibody that recognises a 72 kdalton glycoprotein expressed by human trophoblasts and a very restricted range of adult tissues; they were analysed by flow cytometry. Concordance analysis supported by segregation data allowed assignment of the gene controlling glycoprotein expression (M6P1) to chromosome 6. Similar analysis with translocation hybrids gave a regional assignment to 6q14-q15. M6P1 is distinct from NT5, coding for 5' nucleotidase, which maps to the same region.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00195819