EFFECT OF THE QUASSINOIDS GLAUCARUBOLONE AND SIMALIKALACTONE D ON GROWTH OF CELLS PERMANENTLY INFECTED WITH FELINE AND HUMAN IMMUNODEFICIENCY VIRUSES AND ON VIRAL INFECTIONS

Growth of Crandall feline kidney cells permanently infected with feline immunodeficiency virus was inhibited by the anti-cancer quassinoid glaucarubolone whereas growth of uninfected cells was not inhibited. Similar results were obtained for human MOLT-4 cells infected with HIV-1. The results sugges...

Full description

Saved in:
Bibliographic Details
Published in:Life sciences (1973) 1997-12, Vol.62 (3), p.213-219
Main Authors: Morré, D.James, Zeichhardt, Heinz, Maxeiner, Hans-Günther, Grünert, Hans-Peter, Sawitzky, Dirk, Grieco, Paul
Format: Article
Language:English
Subjects:
AIDS/HIV
Animals
Antineoplastic Agents, Phytogenic - pharmacology
antiviral
Cats
Cell Division - drug effects
Cell Transformation, Viral - drug effects
feline immunodeficiency virus
Glaucarubin - analogs & derivatives
Glaucarubin - pharmacology
glaucarubolone
HIV-1
HIV-1 - drug effects
Humans
Immunodeficiency Virus, Feline - drug effects
NADH oxidase
quassinoids
Quassins
simalikalactone D
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Growth of Crandall feline kidney cells permanently infected with feline immunodeficiency virus was inhibited by the anti-cancer quassinoid glaucarubolone whereas growth of uninfected cells was not inhibited. Similar results were obtained for human MOLT-4 cells infected with HIV-1. The results suggest that cell lines permanently infected with either the feline or the human lentivirus exhibit growth response characteristics to the quassinoids in common with other cell lines malignantly transformed. In addition the quassinoids may delay viral infection suggesting some commonality between the mechanism responsible for inhibition of the growth of the transformed phenotype and viral infection.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(97)01089-8