Kinetics of homeostatic behavior of receptor–enzyme systems under the action of physiologically active compounds

We describe two types of models. In the first one it is assumed that regulation of enzyme activity occurs by the product of the enzyme reaction. In the second it is assumed that concomitant action of ligand occurs on at least two targets with opposite effects (dual-action model). Kinetic analysis of...

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Bibliographic Details
Published in:BioSystems 1998, Vol.45 (1), p.77-85
Main Authors: Ilyina, Anna D., Zaitsev, Sergei V., Grishina, Irina A., Varfolomeev, Sergei D.
Format: Article
Language:English
Subjects:
Dual-action model
Enzymes - metabolism
Homeostasis
Kinetics
Models, Biological
Negative feedback model
Receptors, Cell Surface - metabolism
Receptor–enzyme system
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Description
Summary:We describe two types of models. In the first one it is assumed that regulation of enzyme activity occurs by the product of the enzyme reaction. In the second it is assumed that concomitant action of ligand occurs on at least two targets with opposite effects (dual-action model). Kinetic analysis of models of the first type shows that homeostatic response with respect to the key metabolite of the receptor–enzyme system is possible only if the enzyme kinetics are described by the equation of zero order. In `dual-action' models, the homeostatic behavior of the system is defined by the mechanisms of compensation of the ligand primary effect.
ISSN:0303-2647
1872-8324
DOI:10.1016/S0303-2647(97)00064-6