Renal Granulomatous Sarcoidosis: Report of Six Cases

Six cases of chronic renal failure related to granulomatous renal sarcoidosis are reported and compared with data in the literature. The particular features of sarcoidosis granulomatous interstitial nephritis should be emphasised because presentation may be misleading. Renal failure usually presents...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 1990, Vol.5 (1), p.18-24
Main Authors: Hannedouche, T., Grateau, G., Noël, L. H., Godin, M., Fillastre, J. P., Grünfeld, J. P., Jungers, P.
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Adult
Aged
Angiotensin-converting enzyme
Biological and medical sciences
Calcitriol
Calcitriol - blood
Calcium - blood
Female
Granulomatosis
Humans
Kidney disease
Kidney Diseases - complications
Kidney Diseases - drug therapy
Kidney Diseases - pathology
Kidney Failure, Chronic - etiology
Kidney Failure, Chronic - pathology
Male
Medical sciences
Middle Aged
Nephritis, Interstitial - etiology
Nephritis, Interstitial - pathology
Sarcoidosis
Sarcoidosis - complications
Sarcoidosis - drug therapy
Sarcoidosis - pathology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:Six cases of chronic renal failure related to granulomatous renal sarcoidosis are reported and compared with data in the literature. The particular features of sarcoidosis granulomatous interstitial nephritis should be emphasised because presentation may be misleading. Renal failure usually presents with a rapidly progressive course, either isolated or associated with mild proteinuria and sterile leukocyturia, while extrarenal localisations may be absent. Diagnosis should be suspected on the basis of elevated or paradoxically normal serum calcium concentrations, due to increased plasma concentrations of calcitriol, while immunoreactive circulating parathormone concentrations are depressed. Calcitriol as well as angiotensinconverting enzyme could represent unregulated secretion products from granulomatous tissue and their plasma concentrations may roughly reflect activity of the disease. Early corticosteroid treatment dramatically improves renal function but long-term renal prognosis may be oblitered due to progressive chronic renal failure related to fibrosis scarring.
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/5.1.18