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Quantitative Determination of Stanozolol and Its Metabolite in Urine by Gas Chromatography/Mass Spectrometry

The amount of stanozolol and 3′-hydroxystanozolol in urine was determined after oral administration of stanozolol. A gas chromatograph/mass selective detector equipped with a capillary column was used for these determinations. The GC/MS was operated in the SIM mode, and m/z 581, 669, and 315 were mo...

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Published in:	Journal of analytical toxicology 1990-03, Vol.14 (2), p.109-112
Main Authors:	Choo, Hea-Young P., Kwon, Oh-Seung, Park, Jongsei
Format:	Article
Language:	English
Subjects:	Administration, Oral Analysis Biological and medical sciences Doping in Sports Excretion Gas chromatography Gas Chromatography-Mass Spectrometry General pharmacology Humans Male Mass spectroscopy Medical sciences Metabolites Oral administration Pharmacology. Drug treatments stanozolol Stanozolol - administration & dosage Stanozolol - urine Steroid hormones Substance Abuse Detection - methods Time Factors Urine
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container_title	Journal of analytical toxicology
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creator	Choo, Hea-Young P. Kwon, Oh-Seung Park, Jongsei
description	The amount of stanozolol and 3′-hydroxystanozolol in urine was determined after oral administration of stanozolol. A gas chromatograph/mass selective detector equipped with a capillary column was used for these determinations. The GC/MS was operated in the SIM mode, and m/z 581, 669, and 315 were monitored for stanozolol, 3′-hydroxystanozolol, and calusterone (internal standard), respectively. The detection limit was approximately 1 ng/mL for both steroids. The maximum excretion rate of stanozolol was reached in 8 h and the maximum of 3′-hydroxystanozolol in 19 h. However, only 3% of the administered amount was recovered in urine.
doi_str_mv	10.1093/jat/14.2.109
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A gas chromatograph/mass selective detector equipped with a capillary column was used for these determinations. The GC/MS was operated in the SIM mode, and m/z 581, 669, and 315 were monitored for stanozolol, 3′-hydroxystanozolol, and calusterone (internal standard), respectively. The detection limit was approximately 1 ng/mL for both steroids. The maximum excretion rate of stanozolol was reached in 8 h and the maximum of 3′-hydroxystanozolol in 19 h. However, only 3% of the administered amount was recovered in urine.</description><subject>Administration, Oral</subject><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Doping in Sports</subject><subject>Excretion</subject><subject>Gas chromatography</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Male</subject><subject>Mass spectroscopy</subject><subject>Medical sciences</subject><subject>Metabolites</subject><subject>Oral administration</subject><subject>Pharmacology. Drug treatments</subject><subject>stanozolol</subject><subject>Stanozolol - administration & dosage</subject><subject>Stanozolol - urine</subject><subject>Steroid hormones</subject><subject>Substance Abuse Detection - methods</subject><subject>Time Factors</subject><subject>Urine</subject><issn>0146-4760</issn><issn>1945-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNqFkcFrFDEUxoModbt68yrkIMVDp5uXZJLJUba6LbRIqZXiZXgzm7GpM5M1yRa3f71pd9mjQiB8-X5874WPkHfAToAZMbvHNAN5wp_UCzIBI8uCSyZekgkDqQqpFXtNDmO8ZwxUpcQBOeCCl0KrCemv1jgmlzC5B0tPbbJhcGNWfqS-o9cJR__oe99THJf0PEV6aRM2vnfJUjfSm-BGS5sNXWCk87vgB0z-Z8DV3WZ2iTHS65VtU362KWzekFcd9tG-3d1TcvPl87f5WXHxdXE-_3RRtBJ0KgQHJSsDWBrTyZJpwVpQ2qoGl6BNs-QArOKQT6sr3RjZgrTSWikZik6IKTna5q6C_722MdWDi63texytX8daGw1SC_1fEEqtDdOQwY__BnMRUnNjeEaPt2gbfIzBdvUquAHDJkPPXJ0Lq0HW_FlNyftd8roZ7HIP7xrK_oedj7HFvgs4ti7uMWUAKvG0YLHFXEz2z97G8KtW-adlfXb7I8-bq--3i7K-En8BNrSsQw</recordid><startdate>19900301</startdate><enddate>19900301</enddate><creator>Choo, Hea-Young P.</creator><creator>Kwon, Oh-Seung</creator><creator>Park, Jongsei</creator><general>Oxford University Press</general><general>Preston</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19900301</creationdate><title>Quantitative Determination of Stanozolol and Its Metabolite in Urine by Gas Chromatography/Mass Spectrometry</title><author>Choo, Hea-Young P. ; Kwon, Oh-Seung ; Park, Jongsei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-32164891a599f450730c167e6bad179bd2110821821c787b94c14e4ee440a3f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Administration, Oral</topic><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Doping in Sports</topic><topic>Excretion</topic><topic>Gas chromatography</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Male</topic><topic>Mass spectroscopy</topic><topic>Medical sciences</topic><topic>Metabolites</topic><topic>Oral administration</topic><topic>Pharmacology. Drug treatments</topic><topic>stanozolol</topic><topic>Stanozolol - administration & dosage</topic><topic>Stanozolol - urine</topic><topic>Steroid hormones</topic><topic>Substance Abuse Detection - methods</topic><topic>Time Factors</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choo, Hea-Young P.</creatorcontrib><creatorcontrib>Kwon, Oh-Seung</creatorcontrib><creatorcontrib>Park, Jongsei</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of analytical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choo, Hea-Young P.</au><au>Kwon, Oh-Seung</au><au>Park, Jongsei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative Determination of Stanozolol and Its Metabolite in Urine by Gas Chromatography/Mass Spectrometry</atitle><jtitle>Journal of analytical toxicology</jtitle><addtitle>Journal of Analytical Toxicology</addtitle><date>1990-03-01</date><risdate>1990</risdate><volume>14</volume><issue>2</issue><spage>109</spage><epage>112</epage><pages>109-112</pages><issn>0146-4760</issn><eissn>1945-2403</eissn><coden>JATOD3</coden><abstract>The amount of stanozolol and 3′-hydroxystanozolol in urine was determined after oral administration of stanozolol. 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subjects	Administration, Oral Analysis Biological and medical sciences Doping in Sports Excretion Gas chromatography Gas Chromatography-Mass Spectrometry General pharmacology Humans Male Mass spectroscopy Medical sciences Metabolites Oral administration Pharmacology. Drug treatments stanozolol Stanozolol - administration & dosage Stanozolol - urine Steroid hormones Substance Abuse Detection - methods Time Factors Urine
title	Quantitative Determination of Stanozolol and Its Metabolite in Urine by Gas Chromatography/Mass Spectrometry
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